ArticleThe Journal of comparative neurology2020
Three-dimensional reconstructions of mouse circumvallate taste buds using serial blockface scanning electron microscopy: I. Cell types and the apical region of the taste bud.
Article in The Journal of comparative neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 77 citations in OpenAlex.
- Taste dysfunction in Long COVID.bioRxiv : the preprint server for biology · 2025Article
- Control of Rhizobia Endosymbiosis by Coupling ER Expansion with Enhanced UPR.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Epitope Tagging with Genome Editing in Mice Reveals That the Proton Channel OTOP1 Is Apically Localized and Not Restricted to Type III "Sour" Taste Receptor Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Bitter taste receptors.Chemical senses · 2025Review
- Potential role of glucagon like peptide 1 in taste receptors.Frontiers in endocrinology · 2025Review
- Article
- The complexities of salt taste reception: insights into the role of TMC4 in chloride taste detection.Frontiers in molecular neuroscience · 2024Review
- Give-and-take of gustation: the interplay between gustatory neurons and taste buds.Chemical senses · 2024Review
- Diversity and evolution of serotonergic cells in taste buds of elasmobranchs and ancestral actinopterygian fish.Cell and tissue research · 2023Article
- Contribution of TRPC3-mediated CaPflugers Archiv : European journal of physiology · 2023Article
- Taste arbor structural variability analyzed across taste regions.The Journal of comparative neurology · 2023Article
- Physiology of the tongue with emphasis on taste transduction.Physiological reviews · 2023Review
- The morphological and functional diversity of apical microvilli.Journal of anatomy · 2023Review
- Expression profile of the zinc transporter ZnT3 in taste cells of rat circumvallate papillae and its role in zinc release, a potential mechanism for taste stimulation.European journal of histochemistry : EJH · 2022Article
- Taste Cells of the Type III Employ CASR to Maintain Steady Serotonin Exocytosis at Variable CaCells · 2022Article
- Morphology and chemical characteristics of taste buds associated with P2X3-immunoreactive afferent nerve endings in the rat incisive papilla.Journal of anatomy · 2022Article
- Taste Bud Connectome: Implications for Taste Information Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The Role of ATP and Purinergic Receptors in Taste Signaling.Handbook of experimental pharmacology · 2022Review
- Immune responses in the injured olfactory and gustatory systems: a role in olfactory receptor neuron and taste bud regeneration?Chemical senses · 2022Review
- Why Taste Is Pharmacology.Handbook of experimental pharmacology · 2022Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Taste buds comprise four types of taste cells: three mature, elongate types, Types I-III; and basally situated, immature postmitotic type, Type IV cells. We employed serial blockface scanning electron microscopy to delineate the characteristics and interrelationships of the taste cells in the circumvallate papillae of adult mice. Type I cells have an indented, elongate nucleus with invaginations, folded plasma membrane, and multiple apical microvilli in the taste pore. Type I microvilli may be either restricted to the bottom of the pore or extend outward reaching midway up into the taste pore. Type II cells (aka receptor cells) possess a large round or oval nucleus, a single apical microvillus extending through the taste pore, and specialized "atypical" mitochondria at functional points of contact with nerve fibers. Type III cells (aka "synaptic cells") are elongate with an indented nucleus, possess a single, apical microvillus extending through the taste pore, and are characterized by a small accumulation of synaptic vesicles at points of contact with nerve fibers. About one-quarter of Type III cells also exhibit an atypical mitochondrion near the presynaptic vesicle clusters at the synapse. Type IV cells (nonproliferative "basal cells") have a nucleus in the lower quarter of the taste bud and a foot process extending to the basement membrane often contacting nerve processes along the way. In murine circumvallate taste buds, Type I cells represent just over 50% of the population, whereas Types II, III, and IV (basal cells) represent 19, 15, and 14%, respectively.
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