ArticleSleep2020
Posttraumatic stress disorder increases the odds of REM sleep behavior disorder and other parasomnias in Veterans with and without comorbid traumatic brain injury.
Article in Sleep, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Post-Traumatic Stress Disorder and Risk of Degenerative Synucleinopathies: Systematic Review and Meta-Analysis.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023Pooled it
- Trial
- Baseline characteristics of the North American prodromal Synucleinopathy cohort.Annals of clinical and translational neurology · 2023Trial
- Sleep impairments in refugees diagnosed with post-traumatic stress disorder: a polysomnographic and self-report study.European journal of psychotraumatology · 2023Trial
- Trial
- Stress and Parkinson's disease: from dysfunctional detection to impaired handling: a narrative review.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Genetic associations between post-traumatic stress disorder and REM-sleep behavior disorder.NPJ Parkinson's disease · 2026Article
- Shared Pathogenic Pathways Between REM Sleep Behavior Disorder and Neurodegenerative and Psychiatric Disorders.medRxiv : the preprint server for health sciences · 2026Article
- The North American Prodromal Synucleinopathy study: protocol for a multi-site, longitudinal, observational study of idiopathic/isolated rapid eye movement sleep behavior disorder.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Heart rate variability impairment during sleep in Veterans with rapid eye movement sleep behaviour disorder, traumatic brain injury, and post-traumatic stress disorder: an early potential window into autonomic dysfunction?Journal of sleep research · 2025Article
- REM Sleep Behavior Disorder as a Prodromal Synucleinopathy: Updates on Clinical and Laboratory Biomarkers, and Implications for Neuroprotective Trials.Current neurology and neuroscience reports · 2025Review
- Post-traumatic stress disorder and REM-sleep behavior disorder: exploring genetic associations and causal links.medRxiv : the preprint server for health sciences · 2025Article
- REM Sleep Behavior Disorder Diagnostic Code Accuracy and Implications in the Real-World Setting.Neurology. Clinical practice · 2025Article
- Isolated REM sleep without atonia and isolated REM sleep behaviour disorder: a study of clinical and prognostic differences.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Feasibility and acceptability for LION, a fully remote, randomized clinical trial within the VA for light therapy to improve sleep in Veterans with and without TBI: An MTBImedRxiv : the preprint server for health sciences · 2024Article
- Rates and Predictors of Rapid Eye Movement Sleep Behavior Disorder Symptoms Among Post-9/11 Veterans.The Journal of neuropsychiatry and clinical neurosciences · 2024Article
- Traumatic brain injury and sleep in military and veteran populations: A literature review.NeuroRehabilitation · 2024Review
- REM parasomnias: Straddling the sleep-wake line.Clinical neurophysiology practice · 2024Article
- Sleep Disturbances Associated With Posttraumatic Stress Disorder.Psychiatric annals · 2023Article
- Parasomnias and Associated Factors Among University Students: A Cross-Sectional Study in Saudi Arabia.Cureus · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
STUDY
objectivesTo describe the crude prevalence of rapid eye movement (REM) sleep behavior disorder (RBD) following traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) in Veterans, given potential relationships between TBI, PTSD, RBD, and neurodegeneration.
methodsVeterans (n = 394; 94% male; 54.4 ± 15.5 years of age) were prospectively/cross-sectionally recruited from the VA Portland Health Care System and completed in-lab video-polysomnography and questionnaires. TBI and PTSD were assessed via diagnostic screening and medical record review. Subjects were categorized into four groups after assessment of REM sleep without atonia (RSWA) and self-reported dream enactment: (1) "Normal," neither RSWA nor dream enactment, (2) "Other Parasomnia," dream enactment without RSWA, (3) "RSWA," isolated-RSWA without dream enactment, and (4) "RBD," RSWA with dream enactment. Crude prevalence, prevalence odds ratio, and prevalence rate for parasomnias across subjects with TBI and/or PTSD were assessed.
resultsOverall prevalence rates were 31%, 7%, and 9% for Other Parasomnia, RSWA, and RBD, respectively. The prevalence rate of RBD increased to 15% in PTSD subjects [age adjusted POR: 2.81 (1.17-4.66)] and to 21% in TBI + PTSD subjects [age adjusted POR: 3.43 (1.20-9.35)]. No subjects met all diagnostic criteria for trauma-associated sleep disorder (TASD), and no overt dream enactment was captured on video.
conclusionsThe prevalence of RBD and related parasomnias is significantly higher in Veterans compared with the general population and is associated with PTSD and TBI + PTSD. Considering the association between idiopathic-RBD and synucleinopathy, it remains unclear whether RBD (and potentially TASD) associated with PTSD or TBI + PTSD similarly increases risk for long-term neurologic sequelae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.