ArticleAging2019
Systematic profiling of alternative splicing events and splicing factors in left- and right-sided colon cancer.
Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- Alternative splicing events show high prognostic values and indicate potential core genes in acute myeloid leukemia.Clinical and experimental medicine · 2026Article
- Rbm25 governs embryonic stem cell identity and fate through transcriptional regulation of pluripotency and epigenetic programs.Stem cell reports · 2026Article
- RBM25 Regulates p38 MAPK Pathway Activation via Exon 16 Skipping of MAP4K4 in a Rat Model of Post-Infarction Heart Failure.FASEB bioAdvances · 2025Article
- NONO links circadian rhythm disruption and enhanced tumor-fibroblast crosstalk in right-sided colorectal cancer.Biomarker research · 2025Article
- Does side matter? Deciphering mechanisms that underpin side-dependent pathogenesis and therapy response in colorectal cancer.Molecular cancer · 2025Review
- Integrating single-cell RNA sequencing with spatial transcriptomics reveal the fibrosis-related genes in hepatocellular carcinoma.Frontiers in immunology · 2025Article
- Alternatively Spliced Isoforms ofJournal of personalized medicine · 2023Article
- Coupling of serum CK20 and hyper-methylatedAging · 2021Article
- The pattern of alternative splicing in lung adenocarcinoma shows novel events correlated with tumorigenesis and immune microenvironment.BMC pulmonary medicine · 2021Article
- Prognostic role and clinical significance of C-reactive protein-lymphocyte ratio in colorectal cancer.Bioengineered · 2021Article
- Identification of prognostic alternative splicing events related to the immune microenvironment of hepatocellular carcinoma.Molecular medicine (Cambridge, Mass.) · 2021Article
- Article
- Immune landscape and prognostic immune-related genes in KRAS-mutant colorectal cancer patients.Journal of translational medicine · 2021Article
- Profiles of alternative splicing events in the diagnosis and prognosis of Gastric Cancer.Journal of Cancer · 2021Article
- Identification of an alternative splicing signature as an independent factor in colon cancer.BMC cancer · 2020Article
- Systematic Profiling of Alternative Splicing for Sarcoma Patients Reveals Novel Prognostic Biomarkers Associated with Tumor Microenvironment and Immune Cells.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Nomogram for predicting overall survival in stage II-III colorectal cancer.Cancer medicine · 2020Article
- Nomogram based on clinical characteristics for preoperative prediction of perineural invasion in gastric cancer.The Journal of international medical research · 2020Article
- Discrete functional and mechanistic roles of chromodomain Y-like 2 (CDYL2) transcript variants in breast cancer growth and metastasis.Theranostics · 2020Article
- Identification of Survival-Associated Alternative Splicing Signatures in Lung Squamous Cell Carcinoma.Frontiers in oncology · 2020Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Left- and right-sided colon cancer (LC and RC) differ substantially in their molecular characteristics and prognoses, and are thus treated using different strategies. We systematically analyzed alternative splicing (AS) events and splicing factors in LC and RC. RNA-seq data were used for genome-wide profiling of AS events that could distinguish LC from RC. The Exon Skip splicing pattern was more common in RC, while the Retained Intron pattern was more common in LC. The AS events that were upregulated in RC were enriched for genes in the axon guidance pathway, while those that were upregulated in LC were enriched for genes in immune-related pathways. Prognostic models based on differentially expressed AS events were built, and a prognostic signature based on these AS events performed well for risk stratification in colon cancer patients. A correlation network of differentially expressed AS events and differentially expressed splicing factors was constructed, and
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.