ArticlePsychoneuroendocrinology2020
Involvement of ventral pallidal vasopressin in the sex-specific regulation of sociosexual motivation in rats.
Article in Psychoneuroendocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 24 citations in OpenAlex.
- Early life stress modulates social behavior via oxytocin and arginine vasopressin in males.European archives of psychiatry and clinical neuroscience · 2026Article
- Ventral pallidum GABA neuron inhibition augments context-appropriate defensive responses to learned threat cues.Neurobiology of stress · 2026Article
- Sex difference in the effects of ventral pallidum vasopressin 1a receptor partial knockdown on social behavior in mice.Hormones and behavior · 2025Article
- The deletion of the arginine vasopressin 1a receptor impairs sexual and maternal behavior.Frontiers in endocrinology · 2025Article
- Transcriptomic landscape of mammalian ventral pallidum at single-cell resolution.Science advances · 2024Article
- Sex differences in the structure and function of the vasopressin system in the ventral pallidum are associated with the sex-specific regulation of social play behavior in juvenile rats.Hormones and behavior · 2024Article
- Ventral pallidal regulation of motivated behaviors and reinforcement.Frontiers in neural circuits · 2023Review
- Modulation of social behavior by distinct vasopressin sources.Frontiers in endocrinology · 2023Review
- Knockdown of sexually differentiated vasopressin expression in the bed nucleus of the stria terminalis reduces social and sexual behaviour in male, but not female, mice.Journal of neuroendocrinology · 2022Article
- Ventral pallidum GABA neurons bidirectionally control opioid relapse across rat behavioral models.Addiction neuroscience · 2022Article
- Neural and Hormonal Basis of Opposite-Sex Preference by Chemosensory Signals.International journal of molecular sciences · 2021Review
- Sex differences in vasopressin 1a receptor regulation of social communication within the lateral habenula and dorsal raphe of mice.Hormones and behavior · 2020Article
- Antidepressant Use During Development May Impair Women's Sexual Desire in Adulthood.The journal of sexual medicine · 2020Article
- The social versus food preference test: A behavioral paradigm for studying competing motivated behaviors in rodents.MethodsX · 2020Article
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4 authors at 1 institution in 1 country.
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Abstract
The ventral pallidum (VP) is a critical node of the mesocorticolimbic reward circuit and is known to modulate social behaviors in rodents. Arginine vasopressin (AVP) signaling via the V1A receptor (V1AR) within the VP is necessary for the expression of socially motivated affiliative behaviors in monogamous voles. However, whether the VP-AVP system regulates socially motivated behaviors in non-monogamous species remains unknown. Here, we determined the extent of AVP fiber innervation in the VP as well as the involvement of the VP-AVP system in sociosexual motivation in adult male and female rats. We found that males have nearly twice the density of AVP-immunoreactive (AVP-ir) fibers in the VP compared to females, suggesting the possibility that males experience enhanced AVP signaling in the VP. We further found that this sex difference in VP-AVP-ir fiber density likely arises from an observed sex difference (males > females) in the percentage of VP-projecting AVP-ir cell bodies located in the bed nucleus of the stria terminalis and medial amygdala. To determine the behavioral implications of this sex difference, we next blocked AVP signaling in the VP by antagonizing VP-V1ARs in male and female rats and tested their preference to investigate an unfamiliar male rat or unfamiliar estrus female rat confined to corrals located on opposite ends of a three-chamber apparatus. Under vehicle conditions, males showed a significantly greater innate preference to investigate an opposite sex over same sex conspecific than estrus females. Interestingly, VP-V1AR antagonism significantly reduced males' opposite sex preference, while enhancing estrus females' opposite sex preference. Importantly, all subjects reliably discriminated between male and female stimulus rats regardless of drug treatment, demonstrating a change in motivational state rather than a perceptual impairment induced by VP-V1AR blockade. These results provide a novel functional link between a sex difference in ventral pallidal AVP fiber density and the sex-specific regulation of a sexually motivated behavior necessary for reproductive success.
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