ArticleCancer epidemiology2019
Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE).
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In one paragraph
Article in Cancer epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
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14citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Smoking and oral and pharyngeal cancer: a meta-analysis.Oncology reviews · 2025Pooled it
- Transoral robotic surgery vs open surgery in head and neck cancer. A systematic review of the literature.Medicina oral, patologia oral y cirugia bucal · 2020Pooled it
- Radiomics in laryngeal squamous cell carcinoma: state of the art.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026Review
- The impact of patient age on the oncological prognosis of oral squamous cell carcinoma.Oral and maxillofacial surgery · 2026Article
- Tobacco use and eligibility for lung cancer screening among dental patients at an academic institution in Houston, Texas.Preventive medicine · 2026Article
- Oral health and the risk of head and neck squamous cell carcinoma: a multicenter case-control study in Iran.Scientific reports · 2025Article
- Laryngeal Cancer in the Modern Era: Evolving Trends in Diagnosis, Treatment, and Survival Outcomes.Journal of clinical medicine · 2025Review
- Association of Patient and Tumor Characteristics With Outcomes in Young Head and Neck Squamous Cell Carcinoma Patients.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2025Article
- Laryngeal Cancer: Epidemiology, Etiology, and Prevention: A Narrative Review.Iranian journal of public health · 2023Review
- Oral Squamous Cell Carcinoma Frequency in Young Patients from Referral Centers Around the World.Head and neck pathology · 2022Article
- A New Online Dynamic Nomogram: Construction and Validation of an Assistant Decision-Making Model for Laryngeal Squamous Cell Carcinoma.Frontiers in oncology · 2022Article
- Combined proteomic and transcriptomic approaches reveal externalized keratin 8 as a potential therapeutic target involved in invasiveness of head and neck cancers.Translational oncology · 2021Article
- Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer.Oral diseases · 2021Review
- Tobacco smoking, chewing habits, alcohol drinking and the risk of head and neck cancer in Nepal.International journal of cancer · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
59 authors at 20 institutions in 14 countries.
Chun-Pin ChangDivision of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine, and Huntsman Cancer Institute, Salt Lake City, UT, United States.
Shen-Chih ChangInternational Agency for Research on Cancer, Lyon, France; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, United States.
Shu-Chun ChuangInstitute of Population Health Sciences, National Health Research Institutes, Taiwan.
Julien BerthillerInternational Agency for Research on Cancer, Lyon, France; Pôle Information Médicale Evaluation Recherche, Hospices Civils de Lyon, France.
Gilles FerroInternational Agency for Research on Cancer, Lyon, France.
Keitaro MatsuoDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan; Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Victor Wünsch-FilhoDepartment of Epidemiology, School of Public Health, University of São Paulo, São Paulo, Brazil.
Tatiana N ToporcovDepartment of Epidemiology, School of Public Health, University of São Paulo, São Paulo, Brazil.
Marcos Brasilino de CarvalhoDepartment of Head and Neck, Heliopolis Hospital, São Paulo, Brazil.
Carlo La VecchiaDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Andrew F OlshanDepartment of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC, United States.
Jose P ZevallosDivision of Head and Neck Surgical Oncology, Department of Otolaryngology/Head and Neck Surgery, Washington University School of Medicine, Saint Louis, MO, United States.
Diego SerrainoCancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Italy.
Joshua MuscatPenn State College of Medicine, Hershey, PA, United States.
Erich M SturgisUniversity of Texas M. D. Anderson Cancer Center, Houston, TX, United States.
Guojun LiUniversity of Texas M. D. Anderson Cancer Center, Houston, TX, United States.
Hal MorgensternDepartments of Epidemiology and Environmental Health Sciences, School of Public Health, and Department of Urology, Medical School, University of Michigan, Ann Arbor, MI, United States.
Fabio LeviInstitute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Luigino Dal MasoCancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Italy.
Elaine SmithCollege of Public Health, University of Iowa, Iowa City, IA, United States.
Karl KelseyBrown University, Providence, RI, United States.
Michael McCleanBrown University, Providence, RI, United States.
Thomas L VaughanFred Hutchinson Cancer Research Center, Seattle, WA, United States.
Philip LazarusWashington State University College of Pharmacy, Spokane, WA, United States.
Heribert RamrothUniversity of Heidelberg, Heidelberg, Germany.
Chu ChenFred Hutchinson Cancer Research Center, Seattle, WA, United States.
Stephen M SchwartzFred Hutchinson Cancer Research Center, Seattle, WA, United States.
Deborah M WinnDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, United States.
Cristina BosettiDepartment of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Valeria EdefontiDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Werner GaravelloDepartment of Otorhinolaryngology, School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Eva NegriDepartment of Biomedical and Clinical Sciences, University of Milan, Italy.
Richard B HayesDivision of Epidemiology, New York University School of Medicine, New York, United States.
Mark P PurdueDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, United States.
Stefania BocciaInstitute of Public Health, Section of Hygiene, Universita Cattolica del Sacro Cuore, Rome, Italy; Fondazione Policlinico Universitario A.Gemelli IRCCS, Rome, Italy.
Gabriella CadoniDepartment of Head and Neck Surgery, Institute of Clinical Otorhinolaryngology, Università Cattolica del Sacro Cuore, Rome, Italy; Istituto di Clinica Otorinolaringoiatrica, Fondazione Policlinico Universitario A.Gemelli IRCCS, Rome, Italy.
Oxana ShanginaCancer Research Centre, Moscow, Russia.
Rosalina KoifmanEscola Nacional de Suade Publica, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.
Maria Paula CuradoACCAMARGO Cancer Center, São Paulo, Brazil.
Marta VilenskyInstitute of Oncology Angel H. Roffo, University of Buenos Aires, Argentina.
Beata SwiatkowskaNofer Institute of Occupational Medicine, Lodz, Poland.
Rolando HerreroInternational Agency for Research on Cancer, Lyon, France.
Silvia FranceschiScientific Directorate, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Italy.
Simone BenhamouNational Institute of Health and Medical Research, Inserm U1018, Villejuif, France.
Leticia FernandezInstitute of Oncology and Radiobiology, Havana, Cuba.
Ana M B MenezesUniversidade Federal de Pelotas, Pelotas, Brazil.
Alexander W DaudtHospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.
Dana MatesNational Institute of Public Health, Bucharest, Romania.
Stimson SchantzNew York Eye and Ear Infirmary, New York, NY, United States.
Guo-Pei YuDepartment of Otolaryngology, School of Medicine, New York Medical College, Valhalla, NY, United States.
Jolanta LissowskaThe M. Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Dept. of Cancer Epidemiology and Prevention, Warsaw, Poland.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Eleonora FabianovaRegional Authority of Public Health in Banska Bystrica, Slovakia.
Peter RudnaiNational Institute of Environmental Health, Budapest, Hungary.
Paul BrennanInternational Agency for Research on Cancer, Lyon, France.
Paolo BoffettaThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Zuo-Feng ZhangDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, United States.
Mia HashibeDivision of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine, and Huntsman Cancer Institute, Salt Lake City, UT, United States.
Yuan-Chin Amy LeeDivision of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine, and Huntsman Cancer Institute, Salt Lake City, UT, United States. Electronic address: amy.lee@utah.edu.
Inserm · FRNational Cancer Institute · USCentro di Riferimento Oncologico · ITUniversity of Milan · ITCentre International de Recherche sur le Cancer · FRIstituti di Ricovero e Cura a Carattere Scientifico · ITBrown University · USNational Health Research Institutes · TWThe University of Texas MD Anderson Cancer Center · USUniversidade de São Paulo · BRAichi Cancer Center · JPEscola Nacional de Saúde Pública · BRFred Hutch Cancer Center · USGerman Cancer Research Center · DEHeidelberg University · DEHospices Civils de Lyon · FRHospital Heliópolis · BRHuntsman Cancer Institute · USInstitute of Social and Preventive Medicine · CHMario Negri Institute for Pharmacological Research · IT
Funding
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3MUCLA SPORE IN LUNG CANCERP50CA090388 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2001 to 2008
$13.0MUDP GLUCURONOSYLTRANSFERASES, DETOXIFICATION OF NNKP01CA068384 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LAZARUS, PHILIP · 1995 to 2005
$8.5MUCLA CANCER EPIDEMIOLOGY TRAINING PROGRAMT32CA009142 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 1986 to 2024
$6.3MThe Boston Collaborative Oral Cancer StudyR01CA078609 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KELSEY, KARL TIMOTHY · 1999 to 2010
$5.3MLUNG CANCER CHEMOPREVENTION WITH CELECOXIB IN EX-SMOKERSU01CA096134 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAO, JENNY T · 2002 to 2007
$5.1MUDPGLUCURONOSYLTRANSFERASE GENOTYPE AND ORAL CANCER RISKR01DE013158 · NIDCR · UNIVERSITY OF SOUTH FLORIDA · PI LAZARUS, PHILIP · 2000 to 2011
$3.6MPatterns of Somatic Gene Alterations in Oral CancerR01CA100679 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KELSEY, KARL TIMOTHY · 2004 to 2012
$2.6MSeroepidemiologic Study of HPV and Oral CancerR01DE013110 · NIDCR · UNIVERSITY OF IOWA · PI SMITH, ELAINE M. · 1999 to 2003
$2.5MMARIJUANA USE AND THE RISKS OF LUNG AND OTHER CANCERSR01DA011386 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MORGENSTERN, HAL M · 1999 to 2003
$1.8MGenetic Predictors for DNA Repair Phenotype in CMMR01CA100264 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WEI, QINGYI · 2004 to 2008
$1.5MEpidemiology of protein glutathiolationK07CA104231 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MUSCAT, JOSHUA E · 2005 to 2009
$681kNCI NIH HHS K07 CA104231NCI NIH HHS P01 CA068384NCI NIH HHS P50 CA090388NCI NIH HHS R01 CA030022NCI NIH HHS R01 CA078609NCI NIH HHS R01 CA100264NCI NIH HHS R01 CA100679NCI NIH HHS R03 CA077954NCI NIH HHS R03 CA113157NCI NIH HHS T32 CA009142NCI NIH HHS U01 CA096134NIDA NIH HHS R01 DA011386NIDCR NIH HHS R01 DE013110NIDCR NIH HHS R01 DE013158NIDCR NIH HHS R03 DE016611NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R21 ES011667World Health Organization 001
Abstract
backgroundTobacco use is a well-established risk factor for head and neck cancer (HNC). However, less is known about the potential impact of exposure to tobacco at an early age on HNC risk.
methodsWe analyzed individual-level data on ever tobacco smokers from 27 case-control studies (17,146 HNC cases and 17,449 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects logistic regression models.
resultsWithout adjusting for tobacco packyears, we observed that younger age at starting tobacco use was associated with an increased HNC risk for ever smokers (OR
conclusionsResults from this pooled analysis suggest that increased HNC risks observed with earlier age at starting tobacco smoking are largely due to longer duration and higher cumulative tobacco exposures.
Indexed as
AdultAgedAge FactorsCase-Control StudiesFemaleHead and Neck NeoplasmsHumansMaleMiddle AgedNicotianaRisk FactorsAge at start of tobacco useHead and neck cancerHypopharyngeal cancerLaryngeal cancerOral cancerOropharyngeal cancer
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