Evidence map›Paper›PMID 31586558›Full record

ArticleDevelopmental biology2020

Alveolar progenitor cells in the mammary gland are dependent on the β4 integrin.

Melanie R Walker, John J Amante, Jiarong Li, Haibo Liu, Lihua Julie Zhu, M Laura Feltri, Hira Lal Goel, Arthur M Mercurio

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Melanie R WalkerDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01605, USA.
John J AmanteDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01605, USA.
Jiarong LiDepartment of Medicine, McGill University, Montreal, Canada.
Haibo LiuDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01605, USA.
Lihua Julie ZhuDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01605, USA.
M Laura FeltriHunter James Kelly Research Institute, Departments of Biochemistry and Neurology, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Hira Lal GoelDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01605, USA.
Arthur M MercurioDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01605, USA. Electronic address: arthur.mercurio@umassmed.edu.
University of Massachusetts Chan Medical School · USMcGill University · CAUniversity at Buffalo, State University of New York · US

Funding

Laminin Receptors and Signals in Schwann CellsR01NS045630 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI SIM, FRASER JAMES · 2003 to 2024
$5.9M
VEGF Signaling in Mammary TumorigenesisR01CA168464 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MERCURIO, ARTHUR M · 2012 to 2021
$3.7M
Integrin splicing and cancer stem cell fateR01CA203439 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MERCURIO, ARTHUR M · 2016 to 2020
$1.9M
Mechanisms of Carcinoma Initiation and DifferentiationR50CA221780 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GOEL, HIRA · 2018 to 2022
$1.1M
NCI NIH HHS R01 CA168464NCI NIH HHS R01 CA203439NCI NIH HHS R50 CA221780NINDS NIH HHS R01 NS045630
6 · The paper itself

Abstract

Understanding how progenitor cell function is regulated in the mammary gland is an important developmental problem that has significant implications for breast cancer. Although it had been assumed that the expression the α6β4 integrin (β4) is restricted to the basal lineage, we report that alveolar progenitor cells in the mouse mammary gland also express this integrin based on analysis of single cell RNA-Seq data. Subsequent experiments using a mouse mammary epithelial cell line (NMuMG) confirmed this finding and revealed that β4 is essential for maintaining progenitor function as assessed by serial passage mammosphere assays. These data were substantiated by analyzing the alveolar progenitor population isolated from nulliparous mouse mammary glands. Based on the finding that the alveolar progenitor cells express Whey Acidic Protein (WAP), WAP-Cre mice were crossed with itgβ4

Indexed as

AnimalsIntegrin beta4Mammary Glands, AnimalMice, Inbred C57BLMice, KnockoutStem CellsIntegrin beta4Itgb4 protein, mouseAlveologenesisIntegrinLactationMammary glandProgenitor cell

Identifiers

PMID31586558
PMCPMC7687040
OpenAlexW2977449701

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.