ArticleJournal of animal science2019
Effects of dietary energy level on appetite and central adenosine monophosphate-activated protein kinase (AMPK) in broilers.
Article in Journal of animal science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Meta-analysis across Nellore cattle populations identifies common metabolic mechanisms that regulate feed efficiency-related traits.BMC genomics · 2022Pooled it
- Interactive effects of dietary apparent metabolizable energy, crude protein, and lysine levels on growth and slaughter performance of starter Pekin ducks.Poultry science · 2026Article
- Dietary energy levels regulate feed intake of broilers through the brain-gut axis.Frontiers in veterinary science · 2026Article
- Responses of house crickets (Orthoptera: Gryllidae) to various dietary gross energy levels: effects on growth performance and nutrient deposition.Journal of insect science (Online) · 2025Article
- Effect of Reduction in Dietary Amino Acids and Energy on Growth Performance and Economic Return of Cobb 700 and Ross 708 Broilers.Animals : an open access journal from MDPI · 2025Article
- Effects of dietary metabolizable energy density and inclusion of oxidized soybean oil on the growth performance, serum biochemical parameters, redox status, and wooden breast incidence of broilers.Journal of animal science · 2025Article
- A bird's-eye overview of molecular mechanisms regulating feed intake in chickens-with mammalian comparisons.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Review
- Analysis of the effects of β-mannanase on immune function and intestinal flora in broilers fed the low energy diet based on 16S rRNA sequencing and metagenomic sequencing.Poultry science · 2024Article
- RNA sequencing transcriptomics and metabolomics in three poultry breeds.Scientific data · 2023Article
- In vivo determination of domestic quail (Coturnix japonica) muscle development by ultrasonography as a function of energy levels.Scientific reports · 2023Article
- Primary Broiler Hepatocytes for Establishment of a Steatosis Model.Veterinary sciences · 2022Article
- Dietary Copper Supplementation Increases Growth Performance by Increasing Feed Intake, Digestibility, and Antioxidant Activity in Rex Rabbits.Biological trace element research · 2021Article
- Nutritional and 13-Week Subchronic Toxicological Evaluation ofInternational journal of environmental research and public health · 2021Article
- Effects of Dietary Energy Level on Performance, Plasma Parameters, and Central AMPK Levels in Stressed Broilers.Frontiers in veterinary science · 2021Article
- Highly nutritious diet resists Salmonella Typhimurium infections by improving intestinal microbiota and morphology in broiler chickens.Poultry science · 2020Article
- Evaluation of the Relationship between Adipose Metabolism Patterns and Secretion of Appetite-Related Endocrines on Chicken.Animals : an open access journal from MDPI · 2020Review
- Effects of dietary corticosterone on the central adenosine monophosphate-activated protein kinase (AMPK) signaling pathway in broiler chickens.Journal of animal science · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adenosine monophosphate-activated protein kinase (AMPK) acts as a sensor of cellular energy changes and is involved in the control of food intake. A total of 216 1-d-old broilers were randomly allotted into 3 treatments with 6 replicates per treatment and 12 broilers in each cage. The dietary treatments included 1) high-energy (HE) diet (3,500 kcal/kg), 2) normal-energy (NE) diet (3,200 kcal/kg), and 3) low-energy (LE) diet (2,900 kcal/kg). The present study was conducted to investigate the effects of dietary energy level on appetite and the central AMPK signal pathway. The results showed that a HE diet increased average daily gain (ADG), whereas a LE diet had the opposite effect (P < 0.05, N = 6). The average daily feed intake (ADFI) of the chickens fed the LE diet was significantly higher than that of the control (P < 0.05, N = 6). Overall, the feed conversion rate gradually decreased with increasing dietary energy level (P < 0.05, N = 6). Moreover, the chickens fed the LE and HE diets demonstrated markedly improved urea content compared with the control group (P < 0.0001, N = 8). The triglyceride (TG) content in the LE group was obviously higher than that in the HE group but showed no change compared with the control (P = 0.0678, N = 8). The abdominal fat rate gradually increased with increased dietary energy level (P = 0.0927, N = 8). The HE group showed downregulated gene expression levels of liver kinase B1 (LKB1), neuropeptide Y (NPY), cholecystokinin (CCK), and glucocorticoid receptor (GR) in the hypothalamus compared with the control group (P < 0.05, N = 8). However, LE treatment significantly increased the mRNA level of AMP-activated protein kinase α2 (AMPKα2) compared with other groups (P = 0.0110, N = 8). In conclusion, a HE diet inhibited appetite and central AMPK signaling. In contrast, a LE diet activated central AMPK and appetite. Overall, the central AMPK signal pathway and appetite were modulated in accordance with the energy level in the diet to regulate nutritional status and maintain energy homeostasis in birds.
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