Genetic Screens to Study GAA/TTC and Inverted Repeat Instability in Saccharomyces cerevisiae.

Wenying Guo, Kirill S Lobachev

Abstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Wenying GuoInstitute for Bioengineering and Bioscience, School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.

Kirill S LobachevInstitute for Bioengineering and Bioscience, School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA. kirill.lobachev@biology.gatech.edu.

Funding

Decoding parametric attributes of auditory working memories from human brain activityR01DC016915 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI AHVENINEN, JYRKI · 2018 to 2022

$3.0M

Identification of distinct pathways for DSB formation at palindromic repeatsR01GM129119 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI LOBACHEV, KIRILL S · 2018 to 2021

$1.2M

NIDCD NIH HHS R01 DC016915NIGMS NIH HHS R01 GM129119

6 · The paper itself

Abstract

Instability of trinucleotide and inverted repeats is a causative factor in the development of a number of neurological diseases, hereditary syndromes, and cancer. To understand the mechanisms that lead to repeat-induced genome destabilization it is important to identify factors that affect repeat metabolism. Here we present an approach that utilizes systematic and unbiased genome-wide screen in yeast Saccharomyces cerevisiae aimed to find genes that govern GAA/TTC and inverted repeat instability. These screens allowed for the identification of more than 30 mutants with increased fragility of both repeat motifs.

Indexed as

Trinucleotide RepeatsDNA Repeat ExpansionDNA ReplicationGenomic InstabilityHumansInverted Repeat SequencesMutationNucleic Acid ConformationSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSaccharomyces cerevisiae ProteinsDouble-strand breaksGenome instabilityGenome-wide screenGross chromosomal rearrangementsInverted repeatsTrinucleotide repeats

Identifiers

PMID31586343

DOI10.1007/978-1-4939-9784-8_6

PMCPMC7098163

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.