Evidence map›Paper›PMID 31586288›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2020

Importance of intensive and prolonged rehabilitative treatment on the Guillain-Barrè syndrome long-term outcome: a retrospective study.

Valeria Prada, Federico Massa, Alexander Salerno, Davide Fregosi, Alessandro Beronio, Carlo Serrati, Antonio Mannironi, Giovanni Mancardi, Angelo Schenone, Luana Benedetti

Abstract read
PubMed Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Patient-reported symptoms and experience following Guillain-Barré syndrome and related conditions: Questionnaire development and validation.Health expectations : an international journal of public participation in health care and health policy · 2022
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Valeria PradaDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, RCCS Policlinico San Martino, University of Genova, Largo Daneo 3, 16132, Genoa, Italy. valeria.prada@gmail.com.ORCID http://orcid.org/0000-0001-5756-0576
Federico MassaDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, RCCS Policlinico San Martino, University of Genova, Largo Daneo 3, 16132, Genoa, Italy.
Alexander SalernoDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, RCCS Policlinico San Martino, University of Genova, Largo Daneo 3, 16132, Genoa, Italy.
Davide FregosiDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, RCCS Policlinico San Martino, University of Genova, Largo Daneo 3, 16132, Genoa, Italy.
Alessandro BeronioDepartment of Neurology, Sant'Andrea Hospital, La Spezia, Italy.
Carlo SerratiDepartment of Neurology, IRCCS Policlinico San Martino, Genoa, Italy.
Antonio MannironiDepartment of Neurology, Sant'Andrea Hospital, La Spezia, Italy.
Giovanni MancardiDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, RCCS Policlinico San Martino, University of Genova, Largo Daneo 3, 16132, Genoa, Italy.
Angelo SchenoneDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, RCCS Policlinico San Martino, University of Genova, Largo Daneo 3, 16132, Genoa, Italy.
Luana BenedettiDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, RCCS Policlinico San Martino, University of Genova, Largo Daneo 3, 16132, Genoa, Italy.
Ospedale Policlinico San Martino · ITCTO Andrea Alesini · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGuillain-Barrè syndrome (GBS) is often associated with a residual disability. Nonetheless, poor and incomplete studies have been published addressed towards the assessment of importance of physiotherapy (FKT) in the recovery. The aim of the study was to explore the effects of prolonged FKT associated with medical therapy and to evaluate the long-term outcome.

methodsA retrospective analysis was carried out on patients with GBS who needed to continue rehabilitation after hospitalization and admitted to the Neurological Department of La Spezia from 2003 to 2017. MRC and GBS-Disability scale (GBS-DS) were performed at the time of greatest clinical disability, after medical therapy, and at the end of the overall FKT. The final outcome evaluation was based on the ability to walk with or without support. ANOVA with Bonferroni post-test were used to compare MRC and GBS-DS.

resultsNinety-six patients were admitted, but only 51 satisfied inclusion criteria. Forty patients performed intensive treatment for an average of 60.95 days, and 31 of them, once discharged, are required to continue FKT as outpatients for a mean period of 96.45 days. The mean value of MRC and GBS-DS post-FKT improved significantly compared with the post-medical therapy. Concerning walking, among the 40 patients who did not walk before therapy, 8 need support after the medical therapy and 4 (11.76%) cannot walk independently at the last follow-up.

conclusionsIn conclusion, FKT associated to medical therapy can improve the outcome of the disease, if performed for periods exceeding 6 months.

Indexed as

AdolescentAdultAgedAged, 80 and overDisability EvaluationDisease ProgressionFemaleGuillain-Barre SyndromeHumansImmunoglobulins, IntravenousMaleMiddle AgedOutcome Assessment, Health CarePersons with DisabilitiesPhysical Therapy ModalitiesRetrospective StudiesImmunoglobulins, IntravenousGuillain-Barrè syndromeNeurological rehabilitationNeuromuscular diseasesPhysical therapyRehabilitation

Identifiers

PMID31586288
OpenAlexW2978397151

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.