ArticleScientific reports2019
Self-motion perception is sensitized in vestibular migraine: pathophysiologic and clinical implications.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- A Sensory Adaptation Program for Individuals With Mal de Débarquement Syndrome: A Case Series.Journal of neurologic physical therapy : JNPT · 2026Article
- Clinical Heterogeneity in Vestibular Migraine Diagnosed Using Bárány Society Criteria: Differences According to Caloric-Test-Based Evidence of Peripheral Vestibular Dysfunction.Journal of clinical neurology (Seoul, Korea) · 2026Article
- Caloric-vHIT Dissociation in Vestibular Migraine: An Observational, Retrospective Case Series Study.Journal of clinical medicine · 2026Article
- Quantitative pupillometry as a marker of autonomic dysregulation in vestibular migraine.Journal of oral & facial pain and headache · 2026Article
- Article
- First episode of "probable benign paroxysmal positional vertigo, spontaneously resolved": a comparative and follow-up study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Observational
- Chronic dizziness: neuro-sensitization and psycho-sensitization.Frontiers in integrative neuroscience · 2026Review
- Association Between Interictal Sensory Hypersensitivities and Vestibular Symptoms in Migraine: A Cross-Sectional Study.Brain and behavior · 2025Article
- Research Progress on the Potential Pathogenesis of Persistent Postural-Perceptual Dizziness.Brain and behavior · 2025Review
- Differential diagnosis of orthostatic dizziness with persistent postural-perceptual dizziness and its underlying mechanisms.Frontiers in neurology · 2025Review
- Sensory processing in medically unexplained pain syndrome. A systematic review.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Focused Update on Migraine and Vertigo Comorbidity.Current pain and headache reports · 2024Review
- Frequency dependence of human thresholds: both perceptual and vestibuloocular reflex thresholds.Journal of neurophysiology · 2024Article
- Intra-individual consistency of vestibular perceptual thresholds.Attention, perception & psychophysics · 2024Article
- Human RAMP1 overexpressing mice are resistant to migraine therapies for motion sensitivity.PloS one · 2024Article
- Your Vestibular Thresholds May Be Lower Than You Think: Cognitive Biases in Vestibular Psychophysics.American journal of audiology · 2023Article
- Dispelling Mist That Obscures Positional Vertigo in Vestibular Migraine.Brain sciences · 2023Article
- Evaluating vestibular contributions to rotation and tilt perception.Experimental brain research · 2023Article
- Earth-vertical motion perception assessment using an elevator: a feasibility study.Scientific reports · 2023Article
- Vestibular perceptual thresholds for rotation about the yaw, roll, and pitch axes.Experimental brain research · 2023Article
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6 authors.
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Abstract
Vestibular migraine (VM) is the most common cause of spontaneous vertigo but remains poorly understood. We investigated the hypothesis that central vestibular pathways are sensitized in VM by measuring self-motion perceptual thresholds in patients and control subjects and by characterizing the vestibulo-ocular reflex (VOR) and vestibular and headache symptom severity. VM patients were abnormally sensitive to roll tilt, which co-modulates semicircular canal and otolith organ activity, but not to motions that activate the canals or otolith organs in isolation, implying sensitization of canal-otolith integration. When tilt thresholds were considered together with vestibular symptom severity or VOR dynamics, VM patients segregated into two clusters. Thresholds in one cluster correlated positively with symptoms and with the VOR time constant; thresholds in the second cluster were uniformly low and independent of symptoms and the time constant. The VM threshold abnormality showed a frequency-dependence that paralleled the brain stem velocity storage mechanism. These results support a pathogenic model where vestibular symptoms emanate from the vestibular nuclei, which are sensitized by migraine-related brainstem regions and simultaneously suppressed by inhibitory feedback from the cerebellar nodulus and uvula, the site of canal-otolith integration. This conceptual framework elucidates VM pathophysiology and could potentially facilitate its diagnosis and treatment.
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