ArticleNature communications2019
Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
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118citing papers in PubMed
11.9field-weighted citation impact, top 1% of its field
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Who cites it
118 citing papers in PubMed, 157 citations in OpenAlex.
- Glutamine Metabolism in Cardiac Hypertrophy.Reviews in cardiovascular medicine · 2026Review
- Fueling fibrosis: BCAT1 links branched-chain amino acid metabolism to collagen production.The Journal of clinical investigation · 2026Article
- Metabolites with a message: impacts on epigenetics and implications for epimetabopathies.EMBO reports · 2026Review
- FAP-targeted gastrodin nanoparticles in responsive hydrogel alleviate cardiac fibrosis via fibroblast metabolic reprogramming.Bioactive materials · 2026Article
- Doxorubicin exposure leads to cardiac fibroblast dysregulation and worsens fibrotic remodeling in the pathological heart.Journal of molecular and cellular cardiology plus · 2026Article
- STIM/Orai-Mediated Store-Operated CaCells · 2026Review
- Article
- Short SCN5A Transcript Yields a NaV1.5 Fragment Influencing Cardiac Metabolism.Circulation research · 2026Article
- Metabolic Reprogramming of Fibroblasts by Extracellular Vesicles: A Therapeutic Axis in Fibrosis.JACC. Basic to translational science · 2026Article
- GPT2-mediated Glutamate to α-Ketoglutaric Acid Conversion in Cardiac Fibroblast Promotes Fibrosis.JACC. Basic to translational science · 2026Article
- Poria cocos-derived exosome-like nanoparticles ameliorate lymphedema by reprogramming fibroblast metabolism via enhanced TCA cycle flux.Journal of nanobiotechnology · 2026Article
- Calcium Signaling in Cardiac Fibroblasts: Roles in Fibrosis and Therapeutic Implications.Cardiovascular drugs and therapy · 2026Review
- Alterations in Mitochondrial DNA in Corneal Fibroblast and Myofibroblast Post Injury.Investigative ophthalmology & visual science · 2026Article
- The gene regulatory networks shaping macrophage plasticity and altered function in fibrosis.Frontiers in immunology · 2026Review
- Calcium dysregulation in diabetic cardiomyopathy & heart failure with preserved ejection fraction.Frontiers in cardiovascular medicine · 2026Review
- Aerobic exercise reduces lactate accumulation and improves cardiac function after myocardial infarction.Frontiers in medicine · 2026Article
- The allostatic triage model of psychopathology (ATP Model): How reallocation of brain energetic resources under stress elicits psychiatric symptoms.Neuroscience and biobehavioral reviews · 2025Review
- Cardiac intermediary metabolism in heart failure: substrate use, signalling roles and therapeutic targets.Nature reviews. Cardiology · 2025Review
- Cancer-associated fibroblasts are associated with neo-adjuvant treatment response in oesophageal adenocarcinoma.British journal of cancer · 2025Article
- Pyruvate kinase splice variants in fibroblasts influence cardiac remodeling after myocardial infarction in male mice.Journal of molecular and cellular cardiology · 2025Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 1 country.
Alyssa A LombardiCenter for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.
Andrew A GibbCenter for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.
Ehtesham ArifCenter for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.
Devin W KolmetzkyCenter for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.
Dhanendra TomarCenter for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.ORCID http://orcid.org/0000-0002-3144-7257
Timothy S LuongoCenter for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.
Pooja JadiyaCenter for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.ORCID http://orcid.org/0000-0003-4807-9304
Emma K MurrayCenter for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.
Pawel K LorkiewiczDepartment of Medicine, Institute of Molecular Cardiology, Diabetes and Obesity Center, University of Louisville, Louisville, KY, 40202, USA.ORCID http://orcid.org/0000-0002-1755-9826
György HajnóczkyDepartment of Pathology Anatomy and Cell Biology, MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Thomas Jefferson University, Philadelphia, PA, 19107, USA.ORCID http://orcid.org/0000-0003-3813-2570
Elizabeth MurphySystems Biology Center, National Heart Lung and Blood Institute, Bethesda, MD, 20892, USA.
Zoltan P AranyTranslational Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19014, USA.
Daniel P KellyTranslational Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19014, USA.
Kenneth B MarguliesTranslational Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19014, USA.
Bradford G HillDepartment of Medicine, Institute of Molecular Cardiology, Diabetes and Obesity Center, University of Louisville, Louisville, KY, 40202, USA.
John W ElrodCenter for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA. elrod@temple.edu.ORCID http://orcid.org/0000-0003-3925-2224
Temple University · USTranslational Therapeutics (United States) · USUniversity of Louisville · USNational Heart Lung and Blood Institute · USThomas Jefferson University · US
Funding
Small and large animal surgery, physiology and histologyP01HL134608 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI Raj Kishore · 2017 to 2026
$21.0MMolecular composition of the mitochondrial calcium uniporter and cardiac pathophysiologyR01HL142271 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI ELROD, JOHN WILLIAM, HAJNOCZKY, GYORGY · 2018 to 2021
$3.0MBiosynthetic Pathways in Cardiac RemodelingR01HL147844 · NHLBI · UNIVERSITY OF LOUISVILLE · PI HILL, BRADFORD GUY, JONES, STEVEN P · 2019 to 2022
$3.0MStructural-functional zoning of the mitochondrion in cardiac Ca2+, ROS, and energetics regulationR01HL142864 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI CSORDAS, GYORGY, SHEU, SHEY-SHING · 2018 to 2021
$2.5MMechanisms of mitochondrial calcium exchange in heart failureR01HL123966 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2014 to 2018
$2.3MMetabolic optimization of cell therapyR01HL130174 · NHLBI · UNIVERSITY OF LOUISVILLE · PI HILL, BRADFORD GUY · 2016 to 2020
$1.9MNovel Molecular Mechanisms of Programmed NecrosisR01HL136954 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2017 to 2020
$1.6MNHLBI NIH HHS R01 HL136954NHLBI NIH HHS R01 HL142271NHLBI NIH HHS R01 HL142864
Abstract
Fibroblast to myofibroblast differentiation is crucial for the initial healing response but excessive myofibroblast activation leads to pathological fibrosis. Therefore, it is imperative to understand the mechanisms underlying myofibroblast formation. Here we report that mitochondrial calcium (
Indexed as
AnimalsCalcium-Binding ProteinsCalcium ChannelsCalcium SignalingCell DifferentiationDisease Models, AnimalDNA MethylationEmbryo, MammalianEpigenesis, GeneticEpigenomeFemaleFibrosisGlycolysisHumansKetoglutaric AcidsMiceCalcium-Binding ProteinsCalcium ChannelsKetoglutaric AcidsMcu protein, mouseMICU1 protein, mouseMitochondrial Membrane Transport ProteinsMitochondrial Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.