ArticleNature communications2019
Atomic-level insight into mRNA processing bodies by combining solid and solution-state NMR spectroscopy.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Current practices in the study of biomolecular condensates: a community comment.Nature communications · 2025Article
- Crucial role of the cGAS N terminus in mediating flowable and functional cGAS-DNA condensate formation via DNA interactions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dipolar Recoupling in Rotating Solids.Chemical reviews · 2024Review
- Solid-state NMR studies of proteins in condensed phases.Magnetic resonance letters · 2024Review
- Super-resolution proximity labeling with enhanced direct identification of biotinylation sites.Communications biology · 2024Article
- Structural basis of protein condensation on microtubules underlying branching microtubule nucleation.Nature communications · 2023Article
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- The influence of tag sequence on recombinant humanized collagen (rhCol) and the evaluation of rhCol on Schwann cell behaviors.Regenerative biomaterials · 2023Article
- A call to order: Examining structured domains in biomolecular condensates.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2023Article
- 14-3-3 Proteins are Potential Regulators of Liquid-Liquid Phase Separation.Cell biochemistry and biophysics · 2022Review
- Low complexity RGG-motif sequence is required for Processing body (P-body) disassembly.Nature communications · 2022Article
- Temporal and spatial characterisation of protein liquid-liquid phase separation using NMR spectroscopy.Nature communications · 2022Article
- RNA length has a non-trivial effect in the stability of biomolecular condensates formed by RNA-binding proteins.PLoS computational biology · 2022Article
- Biological solid-state NMR: Integrative across different scientific disciplines.Journal of structural biology: X · 2022Article
- 'RNA modulation of transport properties and stability in phase-separated condensates.Biophysical journal · 2021Article
- Biophysical studies of phase separation integrating experimental and computational methods.Current opinion in structural biology · 2021Review
- Impact of crowded environments on binding between protein and single-stranded DNA.Scientific reports · 2021Article
- Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation.Nature chemical biology · 2021Article
- EDC3 phosphorylation regulates growth and invasion through controlling P-body formation and dynamics.EMBO reports · 2021Article
- Solid-state NMR spectroscopy.Nature reviews. Methods primers · 2021Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liquid-liquid phase separation is increasingly recognized as a process involved in cellular organization. Thus far, a detailed structural characterization of this intrinsically heterogeneous process has been challenging. Here we combine solid- and solution-state NMR spectroscopy to obtain atomic-level insights into the assembly and maturation of cytoplasmic processing bodies that contain mRNA as well as enzymes involved in mRNA degradation. In detail, we have studied the enhancer of decapping 3 (Edc3) protein that is a central hub for processing body formation in yeast. Our results reveal that Edc3 domains exhibit diverse levels of structural organization and dynamics after liquid-liquid phase separation. In addition, we find that interactions between the different Edc3 domains and between Edc3 and RNA in solution are largely preserved in the condensed protein state, allowing processing bodies to rapidly form and dissociate upon small alterations in the cellular environment.
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