ArticleNature communications2019
Modular synthesis of α-fluorinated arylmethanes via desulfonylative cross-coupling.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Nickel-catalyzed divergent sulfonations of propargylic carbonate.Nature communications · 2026Article
- Photo-induced decarboxylative radical cascade cyclization of unactivated alkenes: access to CF- and CFRSC advances · 2025Article
- Palladium-Catalyzed Decarbonylative Coupling of (Hetero)Aryl Boronate Esters with Difluorobenzyl Glutarimides.Organic letters · 2023Article
- Regiodivergent synthesis of sulfone-tethered lactam-lactones bearing four contiguous stereocenters.RSC advances · 2023Article
- An Empirical Quantitative Structure-Activity Relationship Equation Assists the Discovery of High-Affinity Phosphodiesterase 4D Inhibitors as Leads to PET Radioligands.Journal of medicinal chemistry · 2023Article
- Palladium-Catalyzed Aryldifluoromethylation of Aryl Halides with Aryldifluoromethyl Trimethylsilanes.Angewandte Chemie (International ed. in English) · 2022Article
- Tricomponent Decarboxysulfonylative Cross-Coupling Facilitates Direct Construction of Aryl Sulfones and Reveals a Mechanistic Dualism in the Acridine/Copper Photocatalytic System.ACS catalysis · 2022Article
- Catalytic Enantioselective Entry to Triflones Featuring a Quaternary Stereocenter.Organic letters · 2022Article
- A Titanium-Catalyzed Reductive α-Desulfonylation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Synthesis of quaternary centres by single electron reduction and alkylation of alkylsulfones.Chemical science · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
α-Fluoromethylarenes are common substructures in pharmaceuticals and agrochemicals, with the introduction of fluorine often resulting in improved biological activity and stability. Despite recent progress, synthetic routes to α-fluorinated diarylmethanes are still rare. Herein we describe the Pd-catalyzed Suzuki-Miyaura cross-coupling of α-fluorinated benzylic triflones with arylboronic acids affording structurally diverse α-fluorinated diarylmethanes. The ease of synthesis of fluorinated triflones as the key starting materials enables powerful late-stage transformations of known biologically active compounds into fluorinated analogs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.