Evidence map›Paper›PMID 31586037›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung.

Alistair L Chenery, Rafid Alhallaf, Zainab Agha, Jesuthas Ajendra, James E Parkinson, Martha M Cooper, Brian H K Chan, Ramon M Eichenberger, Lindsay A Dent, Avril A B Robertson and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. NLRP3 Regulates IL-4 Expression in TOXFrontiers in immunology · 2021
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Alistair L CheneryWellcome Centre for Cell-Matrix Research, Manchester M13 9PT, United Kingdom.ORCID 0000-0001-8755-461X
Rafid AlhallafCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Smithfield, Queensland 4878, Australia.
Zainab AghaCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Smithfield, Queensland 4878, Australia.ORCID 0000-0003-0294-5385
Jesuthas AjendraWellcome Centre for Cell-Matrix Research, Manchester M13 9PT, United Kingdom.
James E ParkinsonWellcome Centre for Cell-Matrix Research, Manchester M13 9PT, United Kingdom.ORCID 0000-0003-4881-5121
Martha M CooperCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Smithfield, Queensland 4878, Australia.
Brian H K ChanWellcome Centre for Cell-Matrix Research, Manchester M13 9PT, United Kingdom.ORCID 0000-0002-9451-4621
Ramon M EichenbergerCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Smithfield, Queensland 4878, Australia.
Lindsay A DentDepartment of Molecular and Biomedical Science, School of Biological Sciences, University of Adelaide, Adelaide, South Australia 5000, Australia; and.ORCID 0000-0002-3521-408X
Avril A B RobertsonSchool of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland 4072, Australia.ORCID 0000-0002-9652-8357
Andreas KupzCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Smithfield, Queensland 4878, Australia.
David BroughLydia Becker Institute for Immunology and Infection, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PL, United Kingdom.ORCID 0000-0002-2250-2381
Alex LoukasCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Smithfield, Queensland 4878, Australia.
Tara E SutherlandLydia Becker Institute for Immunology and Infection, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PL, United Kingdom.ORCID 0000-0001-9334-8206
Judith E AllenWellcome Centre for Cell-Matrix Research, Manchester M13 9PT, United Kingdom; judi.allen@manchester.ac.uk paul.giacomin@jcu.edu.au.ORCID 0000-0002-3829-066X
Paul R GiacominCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Smithfield, Queensland 4878, Australia; judi.allen@manchester.ac.uk paul.giacomin@jcu.edu.au.ORCID 0000-0002-6326-6792
Australian Institute of Tropical Health and Medicine · AUManchester Academic Health Science Centre · GBThe University of Adelaide · AUThe University of Queensland · AU

Funding

Medical Research Council MR/J001929/1Medical Research Council MR/K01207X/1Medical Research Council MR/K01207X/2Medical Research Council MR/K026666/1Medical Research Council MR/L011840/1Medical Research Council MR/N003586/1MRF_ MRF-009-0002-RG-SUTHEWellcome TrustWellcome Trust 106898/A/15/Z
6 · The paper itself

Abstract

Alternatively activated macrophages are essential effector cells during type 2 immunity and tissue repair following helminth infections. We previously showed that Ym1, an alternative activation marker, can drive innate IL-1R-dependent neutrophil recruitment during infection with the lung-migrating nematode,

Indexed as

Animalsbeta-N-AcetylhexosaminidasesCaspase 1Chemotaxis, LeukocyteEosinophiliaFuransHeterocyclic Compounds, 4 or More RingsImmunity, InnateIndenesInflammasomesInterleukin-4LectinsLungLung Diseases, ParasiticMacrophages, AlveolarMicebeta-N-AcetylhexosaminidasesCasp1 protein, mouseCaspase 1Chil3 protein, mouseFuransHeterocyclic Compounds, 4 or More RingsIndenesInflammasomesInterleukin-4LectinsN-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamideNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseSulfonamidesSulfones

Identifiers

PMID31586037
PMCPMC6826118
OpenAlexW2978206959

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.