Evidence map›Paper›PMID 31586002›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2020

First-in-Humans Imaging with

Neeta Pandit-Taskar, Michael A Postow, Matthew D Hellmann, James J Harding, Christopher A Barker, Joseph A O'Donoghue, Martha Ziolkowska, Shutian Ruan, Serge K Lyashchenko, Frank Tsai and 11 more

Open access · bronzeAbstract readClinical Trial, Phase I
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed, 3 pooled it
24.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

148 citing papers in PubMed, 3 syntheses or guidelines pooled it, 255 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. CD8 PET imaging with [Journal for immunotherapy of cancer · 2026
    Trial
  5. Trial
  6. Trial
  7. Review
  8. Article
  9. Immuno-positron emission tomography in cardiovascular disease: Advances, challenges, and opportunities.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2026
    Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Can Nuclear Imaging Detect Trained Immunity in Cardiovascular Disease?Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  18. Review
  19. Review
  20. Imaging Immunotherapy.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review

88 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 1 country.

Neeta Pandit-TaskarDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York pandit-n@mskcc.org.
Michael A PostowDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Matthew D HellmannParker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York.
James J HardingDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Christopher A BarkerDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Joseph A O'DonoghueDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.
Martha ZiolkowskaDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Shutian RuanDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Serge K LyashchenkoMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Frank TsaiHonor Health, Scottsdale, Arizona.
Michael FarwellUniversity of Pennsylvania, Philadelphia, Pennsylvania.
Tara C MitchellUniversity of Pennsylvania, Philadelphia, Pennsylvania.
Ron KornImaging Endpoints, Scottsdale, Arizona.
William LeImaginAb, Inc., Inglewood, California; and.
Jason S LewisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Wolfgang A WeberDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Deepak BeheraImaginAb, Inc., Inglewood, California; and.
Ian WilsonImaginAb, Inc., Inglewood, California; and.
Michael GordonHonor Health, Scottsdale, Arizona.
Anna M WuImaginAb, Inc., Inglewood, California; and.
Jedd D WolchokDepartment of Medicine, Weill Cornell Medical College, New York, New York.
Memorial Sloan Kettering Cancer Center · USImaginAb (United States) · USCornell University · USHonorHealth · USUniversity of Pennsylvania · USVitalant · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Immunotherapy is becoming the mainstay for treatment of a variety of malignancies, but only a subset of patients responds to treatment. Tumor-infiltrating CD8-positive (CD8+) T lymphocytes play a central role in antitumor immune responses. Noninvasive imaging of CD8+ T cells may provide new insights into the mechanisms of immunotherapy and potentially predict treatment response. We are studying the safety and utility of

Indexed as

RadioisotopesZirconiumAdultAgedAged, 80 and overBiological TransportCD8 AntigensFemaleHumansImmunoconjugatesMaleMiddle AgedNeoplasm MetastasisNeoplasmsPositron Emission Tomography Computed TomographyTissue DistributionCD8 AntigensImmunoconjugatesRadioisotopesZirconiumZirconium-8989Zr-IAB22M2C PETCD8+ T celllung cancermelanomaminibody

Identifiers

PMID31586002
PMCPMC7198374
OpenAlexW2977430086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.