Evidence map›Paper›PMID 31585996›Full record

ArticleApplied and environmental microbiology2019

Phenylacetyl Coenzyme A, Not Phenylacetic Acid, Attenuates CepIR-Regulated Virulence in Burkholderia cenocepacia.

Tasia Joy Lightly, Kara L Frejuk, Marie-Christine Groleau, Laurent R Chiarelli, Cor Ras, Silvia Buroni, Eric Déziel, John L Sorensen, Silvia T Cardona

Open access · bronzeAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

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  8. Review
  9. Methodological tools to study species of the genus Burkholderia.Applied microbiology and biotechnology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Tasia Joy LightlyDepartment of Microbiology, University of Manitoba, Winnipeg, Canada.
Kara L FrejukDepartment of Microbiology, University of Manitoba, Winnipeg, Canada.
Marie-Christine GroleauArmand-Frappier Santé Biotechnologie Center, Institut National de la Recherche Scientifique, Laval, Canada.
Laurent R ChiarelliDepartment of Biology and Biotechnology Lazzaro Spallanzani, University of Pavia, Pavia, Italy.ORCID 0000-0003-0348-9764
Cor RasDepartment of Biotechnology, Delft University of Technology, Delft, The Netherlands.
Silvia BuroniDepartment of Biology and Biotechnology Lazzaro Spallanzani, University of Pavia, Pavia, Italy.
Eric DézielArmand-Frappier Santé Biotechnologie Center, Institut National de la Recherche Scientifique, Laval, Canada.ORCID 0000-0002-4609-0115
John L SorensenDepartment of Chemistry, University of Manitoba, Winnipeg, Canada.
Silvia T CardonaDepartment of Microbiology, University of Manitoba, Winnipeg, Canada Silvia.Cardona@umanitoba.ca.ORCID 0000-0002-0629-8886
University of Manitoba · CAInstitut National de la Recherche Scientifique · CAUniversity of Pavia · ITDelft University of Technology · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During phenylalanine catabolism, phenylacetic acid (PAA) is converted to phenylacetyl coenzyme A (PAA-CoA) by a ligase, PaaK, and then PAA-CoA is epoxidized by a multicomponent monooxygenase, PaaABCDE, before further degradation through the tricarboxylic acid (TCA) cycle. In the opportunistic pathogen

Indexed as

Acetyl Coenzyme ABacterial ProteinsBiodegradation, EnvironmentalBurkholderia cenocepaciaChromatography, LiquidGene Expression Regulation, BacterialMetabolic Networks and PathwaysPhenylacetatesQuorum SensingSequence DeletionTandem Mass SpectrometryTranscriptomeVirulenceVirulence FactorsAcetyl Coenzyme ABacterial ProteinsPhenylacetatesphenylacetic acidphenylacetyl-coenzyme AVirulence FactorsBurkholderiaBurkholderia cenocepaciaBurkholderia cepacia complexCepIRCepRmetabolic regulationphenylacetatephenylacetic acidphenylacetyl-CoAquorum sensing

Identifiers

PMID31585996
PMCPMC6881814
OpenAlexW2979806703

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.