Evidence map›Paper›PMID 31585954›Full record

ArticleGenetics2019

Body Size and Tissue-Scaling Is Regulated by Motoneuron-Derived Activinß in

Lindsay Moss-Taylor, Ambuj Upadhyay, Xueyang Pan, Myung-Jun Kim, Michael B O'Connor

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. A symbiotic gene stimulates aggressive behavior favoring the survival of parasitized caterpillars.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  11. Reciprocal interactions between transforming growth factor beta signaling and collagens: Insights from Caenorhabditis elegans.Developmental dynamics : an official publication of the American Association of Anatomists · 2022
    Article
  12. Article
  13. Development (Cambridge, England) · 2021
    Article
  14. Review
  15. Article
  16. Feedback regulation of BMP signaling byMolecular biology of the cell · 2020
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lindsay Moss-Taylor *Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455.ORCID 0000-0001-9242-2144
Ambuj Upadhyay *Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455.ORCID 0000-0002-8232-3721
Xueyang PanDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455.ORCID 0000-0003-4453-4971
Myung-Jun KimDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455.
Michael B O'ConnorDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455 moconnor@umn.edu.ORCID 0000-0002-3067-5506
University of Minnesota · US

Funding

Inter-organ signals regulating metabolism, physiology and developmental timingR35GM118029 · NIGMS · UNIVERSITY OF MINNESOTA · PI O'CONNOR, MICHAEL BRENDAN · 2016 to 2025
$3.8M
NIGMS NIH HHS R35 GM118029
6 · The paper itself

Abstract

Correct scaling of body and organ size is crucial for proper development, and the survival of all organisms. Perturbations in circulating hormones, including insulins and steroids, are largely responsible for changing body size in response to both genetic and environmental factors. Such perturbations typically produce adults whose organs and appendages scale proportionately with final size. The identity of additional factors that might contribute to scaling of organs and appendages with body size is unknown. Here, we report that loss-of-function mutations in

Indexed as

Body SizeAgingAnimalsCell NucleusDrosophila melanogasterDrosophila ProteinsFemaleLarvaMaleMotor NeuronsMusclesMutationOrgan SizePupaSignal TransductionDrosophila ProteinsActivinbody sizehormonesmotoneuronTGF-β

Identifiers

PMID31585954
PMCPMC6893369
OpenAlexW2977803521

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.