ArticleThe lancet. HIV2019
Adolescent HIV treatment in South Africa's national HIV programme: a retrospective cohort study.
Article in The lancet. HIV, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 43 papers.
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43 citing papers in PubMed, 73 citations in OpenAlex.
- Sociobehavioral determinants of nonretention among adolescents and young adults with HIV.AIDS (London, England) · 2025Trial
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- A cross-sectional study of viral load suppression among youth living with HIV in Namibia.Southern African journal of HIV medicine · 2026Article
- Risk of lymphoma among people with HIV in the United States, 2001-2019.Journal of the National Cancer Institute · 2025Article
- Comparison of sexual risk behaviors among Zambian adolescent girls and young women living with and without HIV.Reproductive health · 2025Article
- Designing Artificial Intelligence-Powered Health Care Assistants to Reach Vulnerable Populations: A Discrete Choice Experiment Among South African University Students.Mayo Clinic proceedings. Digital health · 2025Article
- Article
- Experiences and perceptions on antiretroviral therapy adherence and non-adherence: a scoping review of young people living with HIV in sub-Saharan Africa.BMC public health · 2025Article
- Record linkage without patient identifiers: Proof of concept using data from South Africa's national HIV program.PLOS global public health · 2025Article
- Article
- Pathways between adverse childhood experiences and viral suppression among male HIV-infected adolescents in South Africa.AIDS care · 2024Article
- Patterns of engagement in care during clients' first 12 months after HIV treatment initiation in South Africa: A retrospective cohort analysis using routinely collected data.PLOS global public health · 2024Article
- Differentiated care for youth in Zimbabwe: Outcomes across the HIV care cascade.PLOS global public health · 2024Article
- The fall-And rise-In hospital-based care for people with HIV in South Africa: 2004-2017.PLOS global public health · 2024Article
- Social support experiences of adolescents living with perinatal HIV in rural Limpopo, South Africa.Southern African journal of HIV medicine · 2024Article
- "If they had a place to live, they would be taking medication": a qualitative study identifying strategies for engaging street-connected young people in the HIV prevention-care continuum in Kenya.Journal of the International AIDS Society · 2023Article
- Determinants and rates of retention in HIV care among adolescents receiving antiretroviral therapy in Windhoek, Namibia: a baseline cohort analysis.BMC public health · 2023Article
- Economic Well-being and Associated Mediating Pathways to Improved Antiretroviral Therapy Adherence Among Adolescents Living With HIV: A Prospective Cohort Study in South Africa.Journal of acquired immune deficiency syndromes (1999) · 2022Article
- The Association of Perceived, Internalized, and Enacted HIV Stigma With Medication Adherence, Barriers to Adherence, and Mental Health Among Young People Living With HIV in Zambia.Stigma and health · 2022Article
- Cohort profile: the South African National Health Laboratory Service (NHLS) National HIV Cohort.BMJ open · 2022Article
Corrections and comments
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- Erratum issued
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe number of South African adolescents receiving HIV care and treatment in South Africa is growing. By use of routinely collected laboratory data from South Africa's National HIV Programme, we aimed to quantify the numbers of adolescents accessing HIV care and treatment over time, characterise the role of perinatal infection in these trends, and estimate proportions of adolescents seeking HIV care and antiretroviral therapy (ART) in South Africa's public sector.
methodsWe did a retrospective, descriptive cohort study of children and adolescents aged 1-19 years accessing care in South Africa's public sector HIV treatment programme from 2005 to 2016 with a CD4 cell count or viral load recorded in South Africa's National Health Laboratory Service database. We estimated the total number of children and adolescents entering HIV care with a CD4 cell count or viral load test result by calendar period, as well as the proportion in care and receiving ART with at least one viral load test result. We stratified analyses by gender and by whether the patient entered care at younger than 15 years (probably perinatally infected) or at 15-19 years (probably infected in adolescence).
findingsWe identified 730 882 patients aged 1-19 years at entry to care between Jan 1, 2005, and Dec 31, 2016. 209 205 (54%) of 388 439 patients entering care younger than 15 years and 301 242 (88%) of 342 443 patients entering care aged 15-19 were female. During the study period, the number of virologically monitored patients aged 15-19 years receiving ART increased from 7949 in 2005-08 to 80 918 in 2013-16. 92 783 (66%) of 140 028 patients aged 15-19 years seeking care started ART by 2016, well below UNAID's target of ART for 90% of those diagnosed. We project that the number of adolescents on ART will continue to rise.
interpretationThe many adolescents aged 15-19 years receiving ART reflect the ageing of children entering care at ages 1-14 years, and increases in care-seeking among horizontally infected adolescents aged 15-19 years. However, many adolescents seeking care do not start ART, suggesting an urgent need for interventions to increase uptake of ART and improve services for this population.
fundingUS National Institutes of Health, and the President's Emergency Plan for AIDS Relief through the US Agency for International Development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.