Evidence map›Paper›PMID 31585624›Full record

ReviewBest practice & research. Clinical haematology2019

Leukaemic variants of cutaneous T-cell lymphoma: Erythrodermic mycosis fungoides and Sézary syndrome.

Xochiquetzal U Martinez, Cosimo Di Raimondo, Farah R Abdulla, Jasmine Zain, Steven T Rosen, Christiane Querfeld

Open access · greenAbstract readReview
In one paragraph

Review in Best practice & research. Clinical haematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Clinical and Prognostic Features of Erythrodermic Cutaneous T-Cell Lymphoma: A Retrospective Study of 35 PatientsTurkish journal of haematology : official journal of Turkish Society of Haematology · 2026
    Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Xochiquetzal U MartinezCity of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USA. Electronic address: xomartinez@coh.org.
Cosimo Di RaimondoCity of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USA; Policlinico Tor Vergata, Viale Oxford 81, 00133, Rome, Italy. Electronic address: cdraimondo@coh.org.
Farah R AbdullaCity of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USA. Electronic address: fabdulla@coh.org.
Jasmine ZainCity of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USA. Electronic address: jazain@coh.org.
Steven T RosenCity of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USA; Beckman Research Institute, 1500 E. Duarte Road, Duarte, CA, 91010, United States. Electronic address: srosen@coh.org.
Christiane QuerfeldCity of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USA; Beckman Research Institute, 1500 E. Duarte Road, Duarte, CA, 91010, United States. Electronic address: cquerfeld@coh.org.
City Of Hope National Medical Center · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3M
Cutaneous T cell lymphoma: a paradigm for dissecting susceptibility and resistance to checkpoint inhibition therapyR01CA229510 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI QUERFELD, CHRISTIANE · 2019 to 2023
$2.8M
NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA229510
6 · The paper itself

Abstract

Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common types of cutaneous lymphoma, accounting for approximately 60% of cutaneous T-cell lymphomas. Diagnosis requires correlation of clinical, histologic, and molecular features. A multitude of factors have been linked to the aetiopathogenesis, however, none have been definitively proven. Erythrodermic MF (E-MF) and SS share overlapping clinical features, such as erythroderma, but are differentiated on the degree of malignant blood involvement. While related, they are considered to be two distinct entities originating from different memory T cell subsets. Differential expression of PD-1 and KIR3DL2 may represent a tool for distinguishing MF and SS, as well as a means of monitoring treatment response. Treatment of E-MF/SS is guided by disease burden, patients' ages and comorbidities, and effect on quality of life. Current treatment options include biologic, targeted, immunologic, and investigational therapies that can provide long term response with minimal side effects. Currently, allogeneic stem cell transplantation is the only potential curative treatment.

Indexed as

Immunologic MemoryMycosis FungoidesSezary SyndromeSkin NeoplasmsT-LymphocytesHumansNeoplasm ProteinsProgrammed Cell Death 1 ReceptorReceptors, KIR3DL2KIR3DL2 protein, humanNeoplasm ProteinsPDCD1 protein, humanProgrammed Cell Death 1 ReceptorReceptors, KIR3DL2Cutaneous T-cell lymphomaErythrodermicInvestigational therapiesLeukaemic variantsMycosis fungoidesSézary syndromeSupportive careTherapeutic strategiesTreatment regimen

Identifiers

PMID31585624
PMCPMC9056079
OpenAlexW2955586853

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.