Evidence map›Paper›PMID 31585544›Full record

ArticleTrials2019

Reducing Asthma Attacks in Children using Exhaled Nitric Oxide as a biomarker to inform treatment strategy: a randomised trial (RAACENO).

S Turner, S C Cotton, C D Emele, R Thomas, S Fielding, E A Gaillard, J C de Jongste, H Morgan, A R Neilson, J Norrie and 3 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

S TurnerChild Health, University of Aberdeen, Aberdeen, UK. s.w.turner@abdn.ac.uk.ORCID http://orcid.org/0000-0001-8393-5060
S C CottonCentre for Healthcare Randomised Trials, University of Aberdeen, Aberdeen, UK.
C D EmeleCentre for Healthcare Randomised Trials, University of Aberdeen, Aberdeen, UK.
R ThomasCentre for Healthcare Randomised Trials, University of Aberdeen, Aberdeen, UK.
S FieldingMedical Statistics Team, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
E A GaillardRespiratory Sciences, University of Leicester, Leicester, UK.
J C de JongsteDepartment of Paediatric Respiratory Medicine and Allergology, Erasmus MC - Sophia Children's Hospital, Rotterdam, Netherlands.
H MorganPostgraduate Education Group, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
A R NeilsonHealth Economics Research Unit, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
J NorrieCentre for Healthcare Randomised Trials, University of Aberdeen, Aberdeen, UK.
M PijnenburgDepartment of Paediatric Respiratory Medicine and Allergology, Erasmus MC - Sophia Children's Hospital, Rotterdam, Netherlands.
D PriceObservational and Pragmatic Research Institute Pte Ltd, Singapore, Singapore.
M ThomasPrimary Care and Population Sciences, University of Southampton, Southampton, UK.
University of Aberdeen · GBErasmus MC - Sophia Children’s Hospital · NLNIHR Southampton Respiratory Biomedical Research Unit · GBUniversity of Leicester · GB

Funding

STUDIES ON AIDS-RELATED OPPORTUNISTIC PATHOGENF06TW001814 · FIC · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI BARROW, WILLIAM · 1992 to 1994
–
Chief Scientist Office HERU1Chief Scientist Office HSRU1Department of Health EME/15/18/14Efficacy and Mechanism Evaluation Programme 15-18-14
6 · The paper itself

Abstract

backgroundChildhood asthma is a common condition. Currently there is no validated objective test which can be used to guide asthma treatment in children. This study tests the hypothesis that the addition of fractional exhaled nitric oxide (F

methodsThis is a multi-centre, randomised controlled study. Children will be included of age 6-16 years who have a diagnosis of asthma, currently use inhaled corticosteroids (ICSs) and have had an exacerbation in the previous 12 months. Exclusion criteria include being unable to provide F DISCUSSION: This study will evaluate whether F

trial registrationISRCTN, ISRCTN67875351. Registered on 12 April 2017. Prospectively registered.

Indexed as

Breath TestsAdministration, InhalationAdolescentAdrenal Cortex HormonesAnti-Asthmatic AgentsAsthmaBiomarkersChildDisease ProgressionExhalationFemaleHumansMaleMulticenter Studies as TopicNitric OxidePredictive Value of TestsAdrenal Cortex HormonesAnti-Asthmatic AgentsBiomarkersNitric Oxide

Identifiers

PMID31585544
PMCPMC6778366
OpenAlexW2978505359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.