ReviewSeminars in respiratory and critical care medicine2019
Influenza Infections and Emergent Viral Infections in Intensive Care Unit.
Review in Seminars in respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Viral Coinfection among COVID-19 Patient Groups: An Update Systematic Review and Meta-Analysis.BioMed research international · 2021Pooled it
- The Artificial-Liver Blood-Purification System Can Effectively Improve Hypercytokinemia for COVID-19.Frontiers in immunology · 2020Trial
- Influenza Associated Encephalopathy, Encephalitis, and Acute Necrotizing Encephalitis in Adults: A Scoping Review of 83 Cases.Neurology international · 2026Review
- Epidemiological characteristics of patients hospitalized with severe complicated influenza in Taiwan from 2010 to 2020: a retrospective study.BMC infectious diseases · 2026Article
- Observational
- Molecular epidemiological analysis of Influenza viruses in Influenza-like illness cases: a retrospective study in Chongqing Hi-Tech Zone, China (2021-2024).Virology journal · 2024Article
- Early predictors of Epstein-Barr virus infection in patients with severe fever with thrombocytopenia syndrome.Virology journal · 2024Article
- Review
- Exploring the immune-inflammatory mechanism of Maxing Shigan Decoction in treating influenza virus A-induced pneumonia based on an integrated strategy of single-cell transcriptomics and systems biology.European journal of medical research · 2024Article
- Enhancing pathogen description and antibiotic regimen selection in community-acquired pneumonia through RT-qPCR assays.Frontiers in microbiology · 2024Article
- Severe forms of influenza infections admitted in intensive care units: Analysis of mortality factors.Influenza and other respiratory viruses · 2023Article
- Viral infections in critical care: a narrative review.Anaesthesia · 2023Review
- Effect of Cytomegalovirus Reactivation on Inflammatory Status and Mortality of Older COVID-19 Patients.International journal of molecular sciences · 2023Article
- Efficacy of ganciclovir in the treatment of cytomegalovirus (CMV) infection in infants and its effect on inflammatory reaction and immune function.American journal of translational research · 2023Article
- Metagenomic-based pathogen surveillance for children with severe pneumonia in pediatric intensive care unit.Frontiers in public health · 2023Article
- Metagenomic next-generation sequencing of bronchoalveolar lavage fluid from children with severe pneumonia in pediatric intensive care unit.Frontiers in cellular and infection microbiology · 2023Article
- Herpesviridae lung reactivation and infection in patients with severe COVID-19 or influenza virus pneumonia: a comparative study.Annals of intensive care · 2022Article
- Flu-IV score: a predictive tool for assessing the risk of invasive mechanical ventilation in patients with influenza-related pneumonia.BMC pulmonary medicine · 2022Article
- Case report: Disseminated herpes simplex virus 1 infection and hemophagocytic lymphohistiocytosis after immunomodulatory therapy in a patient with coronavirus disease 2019.Frontiers in medicine · 2022Article
- Hypercoagulability of COVID-19 and Neurological Complications: A Review.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Critically ill patients are admitted to an intensive care unit (ICU) for multiple reasons. In this study, we aim to analyze the current evidence and findings associated with influenza and other emergent viral infections, namely, herpes simplex virus type 1 (HSV-1), Epstein-Barr virus (EBV), and cytomegalovirus (CMV).Among medical conditions, community-acquired respiratory infections are the most frequent reason for ventilatory support in ICUs. Community-acquired pneumonia in a severe form including the need of invasive mechanical ventilation and/or vasopressors is associated with high mortality rates. However, after the pandemic that occurred in 2009 by H1N1 influenza, the number of cases being admitted to ICUs with viral infections is on the rise. Patients in whom an etiology would not have been identified in the past are currently being tested with more sensitive viral molecular diagnostic tools, and patients being admitted to ICUs have more preexisting medical conditions that can predispose to viral infections. Viral infections can trigger the dysregulation of the immune system by inducing a massive cytokine response. This cytokine storm can cause endothelial damage and dysfunction, deregulation of coagulation, and, consequently, alteration of microvascular permeability, tissue edema, and shock. In severe influenza, this vascular hyperpermeability can lead to acute lung injury, multiorgan failure, and encephalopathy. In immunocompetent patients, the most common viral infections are respiratory, and influenza should be considered in patients with severe respiratory failure being admitted to ICU. Seasonality and coinfection are two important features when considering influenza as a pathogen in critically ill patients.Herpesviridae (HSV, CMV, and EBV) may reactivate in ICU patients, and their reactivation is associated with morbidity/mortality. However, whether a specific treatment may impact on outcome remains to be determined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.