ArticleSocial science & medicine (1982)2019
Pathways linking combinations of early-life adversities to adult mortality: Tales that vary by gender.
Article in Social science & medicine (1982), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of latent class analysis in psychology: Examining the gap between guidelines and research practice.Behavior research methods · 2025Pooled it
- Adverse Childhood Experiences and Mortality at Old Age: A Longitudinal Study from the Japan Gerontological Evaluation Study.Journal of child & adolescent trauma · 2026Article
- Associations of childhood economic and psychosocial conditions with later-life cognitive function: a longitudinal analysis of the China health and retirement longitudinal study (2011-2020).BMC public health · 2026Article
- The effects of parental education on male mortality: evidence from the first wave of compulsory schooling laws.Journal of population economics · 2025Article
- The Siren Song of Cicadas: Early-Life Pesticide Exposure and Later-Life Male Mortality.Journal of environmental economics and management · 2024Article
- Long-Term Health Benefits of Occupational Licensing: Evidence from Midwifery Laws.Journal of health economics · 2023Article
- Associations of Early-Life Adversity With Later-Life Epigenetic Aging Profiles in the Multi-Ethnic Study of Atherosclerosis.American journal of epidemiology · 2023Article
- Long-run intergenerational health benefits of women empowerment: Evidence from suffrage movements in the US.Health economics · 2023Article
- Association between childhood adversities and premature and potentially avoidable mortality in adulthood: a population-based study.BMC public health · 2023Article
- Targeting the Arginine Vasopressin VNeuropsychiatric disease and treatment · 2023Review
- Childhood adversities and rate of adulthood all-cause hospitalization in the general population: A retrospective cohort study.PloS one · 2023Article
- The Long Arm of Prospective Childhood Income for Mature Adult Health in the United States.Journal of health and social behavior · 2022Article
- Adverse childhood experiences and premature mortality through mid-adulthood: A five-decade prospective study.Lancet regional health. Americas · 2022Article
- Worse health-related quality of life, impaired functioning and psychiatric comorbidities are associated with excess mortality in patients with severe chronic pain.European journal of pain (London, England) · 2022Observational
- An Examination of the Components of Toxic Stress in Childhood and Biological Markers of Physical Health in Emerging Adulthood.Journal of child & adolescent trauma · 2022Article
- Protective and Risk Factors at the Intersection of Chronic Pain, Depression, Anxiety, and Somatic Amplification: A Latent Profile Approach.Journal of pain research · 2022Article
- Gendered racial disparities in health of parents with children with developmental disabilities.Frontiers in psychology · 2022Article
- Cardiovascular Health at the Intersection of Race and Gender: Identifying Life-Course Processes to Reduce Health Disparities.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021Article
- Early-Life Adversities and Recalcitrant Smoking in Midlife: An Examination of Gender and Life-Course Pathways.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2020Article
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Authors and funding
2 authors.
Funding
Abstract
rationaleSocioeconomic disadvantage, family instability, and abuse are widely studied early-life adversities (ELAs) that may co-occur in the lives of many. The detrimental effects of these adversities may result in elevated risk of mortality in midlife and old age.
objectiveWe investigate how combinations of these three ELAs affect later-life mortality and the life-course mediators that explain the associations.
methodData come from the first two waves of the Midlife in the United States (MIDUS) study and mortality records over a 20-year period (1995/96-2015). We used latent class analysis (LCA) to identify patterns of ELAs across the three domains and incorporated four life-course mediators: material, psychological, social resources, healthy lifestyle and substance abuse.
resultsLCA yielded six distinct combinations of ELAs, with patterns of socioeconomic status (SES) and abuse being most salient. We found that childhood abuse exists across all levels of childhood SES. For both genders, individuals who experienced low SES combined with frequent abuse have the highest risk of death. For women but not men, frequent abuse increases the risk of mortality even if they grew up in middle or high SES families. For both genders, material resource is a significant contributor on the pathway from ELAs to mortality. Life-course mediators partially accounted for the observed associations between ELAs and mortality, but attenuation was stronger for men than women. This is partially attributed to the stronger direct effects of life-course resources on mortality for men than women.
conclusionsOur findings suggest that ELAs are an important determinant of mortality in midlife and old age. Traumatic experiences during the critical period of early life may compromise later-life heath more for women than men.
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