ArticleNeurobiology of aging2019
Dynamic change of cognitive reserve: associations with changes in brain, cognition, and diagnosis.
Article in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 52 citations in OpenAlex.
- Machine learning assessment of cognitive reserve using functional near-infrared spectroscopy in older adults with cognitive frailty.GeroScience · 2026Article
- Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease.Neurology · 2026Article
- Domain-specific changes in everyday cognition: Associations with diagnosis change and gray matter volume change.Neuropsychology · 2026Article
- The association between cognitive reserve and cognitive function trajectories in older adults: a Chinese nationally representative cohort study with group-based trajectory modeling.BMC public health · 2025Article
- Case Report: Neuropsychological Profile of a Patient With Intravascular Large B-Cell Lymphoma Following Infection and Vaccination.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Article
- Cognitive reserve can impact trajectories in ageing: a longitudinal study.Aging clinical and experimental research · 2025Article
- Dynamic lifetime risk prediction of Alzheimer's disease with longitudinal cognitive assessment measurements.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Carotid revascularization improves cognition in patients with carotid stenosis.Scientific reports · 2025Article
- Left Frontal Connectivity Moderates the Relationship between Inflammation and Cognitive Performance in Patients following Cardiac Surgery: A Longitudinal fMRI Study.Research (Washington, D.C.) · 2025Article
- Sex differences in the association between episodic memory residual reserve index and change in executive function.Aging brain · 2025Article
- Cognitive reserve against Alzheimer's pathology is linked to brain activity during memory formation.Nature communications · 2024Observational
- Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration.Alzheimer's research & therapy · 2024Article
- Development of a machine learning algorithm to predict the residual cognitive reserve index.Brain communications · 2024Article
- Cognitive reserve moderates the association between cerebral blood flow and language performance in older adults with mild cognitive impairment.Neurobiology of aging · 2023Article
- Connectome-based predictive modelling of cognitive reserve using task-based functional connectivity.The European journal of neuroscience · 2023Article
- The role of cognitive and brain reserve in memory decline and atrophy rate in mid and late-life: The SMART-MR study.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- Effects of aging on cognitive and brain inter-network integration patterns underlying usual and dual-task gait performance.Frontiers in aging neuroscience · 2022Article
- Residual reserve index modifies the effect of amyloid pathology on fluorodeoxyglucose metabolism: Implications for efficiency and capacity in cognitive reserve.Frontiers in aging neuroscience · 2022Article
- Impact of Cardiovascular Risk Factors in Adolescence, Young Adulthood, and Midlife on Late-Life Cognition: Study of Healthy Aging in African Americans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Verbal intelligence is a more robust cross-sectional measure of cognitive reserve than level of education in healthy older adults.Alzheimer's research & therapy · 2021Article
Corrections and comments
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Authors and funding
13 authors at 11 institutions in 2 countries.
Funding
Abstract
Cognitive reserve is inherently a dynamic construct; however, traditional methods of estimating reserve have focused on static proxy variables. A recently proposed psychometric approach entails modeling reserve as residual cognition not explained by demographic and brain variables. In this study, we extended this approach to longitudinal measurement and examined how change in reserve relates to clinical outcomes in late life and influences the effect of brain atrophy on cognitive decline. Results indicated that cognitive reserve changes were associated with progression of clinical diagnosis. More rapid depletion of cognitive reserve was associated with faster decline in nonmemory cognitive functions, even after accounting for longitudinal brain atrophy. The effect of longitudinal brain atrophy on cognitive decline differed based on the extent to which an individual's reserve changed. Whereas depletion of reserve appeared to unmask the effects of brain atrophy on cognitive decline, maintenance of reserve buffered against the negative effects of brain atrophy. Study results highlight that changes in reserve may have important implications for individual differences in cognitive aging trajectories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.