ArticleNeurobiology of aging2019
Association of white matter microstructural integrity with cognition and dementia.
Article in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- White matter alterations in mild cognitive impairment revealed by meta-analysis of diffusion tensor imaging using tract-based spatial statistics.Brain imaging and behavior · 2023Pooled it
- Brain-cognition relationships and treatment outcome in treatment-resistant late-life depression.Nature communications · 2026Article
- Association between allostatic load and accelerated white matter brain aging: findings from the UK Biobank.American journal of epidemiology · 2025Article
- Identification of novel therapeutic targets for cognitive performance and associations with brain health.Translational psychiatry · 2025Article
- Assessing Exercise and Fitness-Related Brain Health Using Multi-modal Magnetic Resonance Imaging Outcomes.Advances in neurobiology · 2025Review
- White matter microstructure in mid- to late adulthood is influenced by pathway-stratified polygenic risk for Alzheimer's disease.Frontiers in neuroscience · 2025Article
- The impact of proton pump inhibitors on brain health based on cross-sectional findings from the Rhineland Study.Scientific reports · 2024Article
- Improved cognition and preserved hippocampal fractional anisotropy in subjects undergoing carotid endarterectomy "CEA preserves cognition & hippocampal structure".Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2024Article
- Cluster-Based White Matter Signatures and the Risk of Dementia, Stroke, and Mortality in Community-Dwelling Adults.Neurology · 2024Article
- Diffusion Tensor Imaging in Boys With Adrenoleukodystrophy: Identification of Cerebral Disease and Association With Neurocognitive Outcomes.Neurology · 2024Article
- Cross-Sectional Associations of Peripheral Hearing, Brain Imaging, and Cognitive Performance With Speech-in-Noise Performance: The Aging and Cognitive Health Evaluation in Elders Brain Magnetic Resonance Imaging Ancillary Study.American journal of audiology · 2024Article
- Association between allostatic load and accelerated white matter brain aging: findings from the UK Biobank.medRxiv : the preprint server for health sciences · 2024Article
- Structural white matter properties and cognitive resilience to tau pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Toward diffusion tensor imaging as a biomarker in neurodegenerative diseases: technical considerations to optimize recordings and data processing.Frontiers in human neuroscience · 2024Review
- Exploring white matter microstructural alterations in mild cognitive impairment: a multimodal diffusion MRI investigation utilizing diffusion kurtosis and free-water imaging.Frontiers in neuroscience · 2024Article
- Can integration of Alzheimer's plasma biomarkers with MRI, cardiovascular, genetics, and lifestyle measures improve cognition prediction?Brain communications · 2024Article
- Cerebral white matter myelination is associated with longitudinal changes in processing speed across the adult lifespan.Brain communications · 2024Article
- White matter abnormalities in aneurysmal and angiographically negative subarachnoid hemorrhage: A diffusion kurtosis imaging study.NeuroImage. Clinical · 2024Article
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Authors and funding
13 authors.
Funding
Abstract
Late-life measures of white matter (WM) microstructural integrity may predict cognitive status, cognitive decline, and incident mild cognitive impairment (MCI) or dementia. We considered participants of the Atherosclerosis Risk in Communities study who underwent cognitive assessment and neuroimaging in 2011-2013 and were followed through 2016-2017 (n = 1775 for analyses of prevalent MCI and dementia, baseline cognitive performance, and longitudinal cognitive change and n = 889 for analyses of incident MCI, dementia, or death). Cross-sectionally, both overall WM fractional anisotropy and overall WM mean diffusivity were strongly associated with baseline cognitive performance and risk of prevalent MCI or dementia. Longitudinally, greater overall WM mean diffusivity was associated with accelerated cognitive decline, as well as incident MCI, incident dementia, and mortality, but WM fractional anisotropy was not robustly associated with cognitive change or incident cognitive impairment. Both cross-sectional and longitudinal associations were attenuated after additionally adjusting for likely downstream pathologic changes. Increased WM mean diffusivity may provide an early indication of dementia pathogenesis.
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