ArticleNeurobiology of aging2019
Interaction between the progression of Alzheimer's disease and fractal degradation.
Article in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Determinants of fractal motor activity regulation: insights from a large community-dwelling multi-ethnic population.Research square · 2026Article
- Delineating cognitive resilience using fractal regulation: Cross-sectional and longitudinal evidence from the Rush Memory and Aging Project.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Altered Motor Activity Patterns within 10-Minute Timescale Predict Incident Clinical Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Article
- Fractal complexity of daily physical activity and cognitive function in a midlife cohort.Scientific reports · 2023Article
- Effects of esketamine on patient-reported outcomes in major depressive disorder with active suicidal ideation and intent: a pooled analysis of two randomized phase 3 trials (ASPIRE I and ASPIRE II).Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Personalized relapse prediction in patients with major depressive disorder using digital biomarkers.Scientific reports · 2023Article
- Correlates of Person-Specific Rates of Change in Sensor-Derived Physical Activity Metrics of Daily Living in the Rush Memory and Aging Project.Sensors (Basel, Switzerland) · 2023Article
- Abnormalities of Rest-Activity and Light Exposure Rhythms Associated with Cognitive Function in Patients with Mild Cognitive Impairment (MCI).Journal of circadian rhythms · 2023Article
- Circadian rhythms in neurodegenerative disorders.Nature reviews. Neurology · 2022Review
- Sleep, rest-activity rhythms and aging: a complex web in Alzheimer's disease?Neurobiology of aging · 2021Article
- Fractal motor activity regulation and sex differences in preclinical Alzheimer's disease pathology.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Adaptive Capacities and Complexity of Heart Rate Variability in Patients With Chronic Obstructive Pulmonary Disease Throughout Pulmonary Rehabilitation.Frontiers in physiology · 2021Article
- Circadian disturbances in Alzheimer's disease progression: a prospective observational cohort study of community-based older adults.The lancet. Healthy longevity · 2020Observational
- Signal Information Prediction of Mortality Identifies Unique Patient Subsets after Severe Traumatic Brain Injury: A Decision-Tree Analysis Approach.Journal of neurotrauma · 2020Observational
- More random motor activity fluctuations predict incident frailty, disability, and mortality.Science translational medicine · 2019Article
- Nonlinear heart rate variability biomarkers for gastric cancer severity: A pilot study.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Many outputs from healthy neurophysiological systems including motor activity display nonrandom fluctuations with fractal scaling behavior as characterized by similar temporal fluctuation patterns across a range of time scales. Degraded fractal regulation predicts adverse consequences including Alzheimer's dementia. We examined longitudinal changes in the scaling behavior of motor activity fluctuations during the progression of Alzheimer's disease (AD) in 1068 participants in the Rush Memory and Aging Project. Motor activity of up to 10 days was recorded annually for up to 13 years. Cognitive assessments and clinical diagnoses were administered annually in the same participants. We found that fractal regulation gradually degraded over time (p < 0.0001) even during the stage with no cognitive impairment. The degradation rate was more than doubled after the diagnosis of mild cognitive impairment and more than doubled further after the diagnosis of Alzheimer's dementia (p's ≤ 0.0005). Besides, the longitudinal degradation of fractal regulation significantly correlated with the decline in cognitive performance throughout the progression from no cognitive impairment to mild cognitive impairment, and to AD (p < 0.001). All effects remained the same in subsequent sensitivity analyses that included only 255 decedents with autopsy-confirmed Alzheimer's pathology. These results indicate that the progression of AD accelerates fractal degradation and that fractal degradation may be an integral part of the process of AD.
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