Evidence map›Paper›PMID 31585330›Full record

ReviewCurrent opinion in neurobiology2019

Functional flexibility in cortical circuits.

Jessica A Cardin

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
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  4. Review
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  6. Review
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  8. NMDA-driven dendritic modulation enables multitask representation learning in hierarchical sensory processing pathways.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Article
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  14. Theoretical foundations of studying criticality in the brain.Network neuroscience (Cambridge, Mass.) · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Jessica A CardinDepartment of Neuroscience, Yale University, New Haven CT 06520, United States; Kavli Institute for Neuroscience, Yale University, New Haven, CT 06520, United States. Electronic address: jess.cardin@yale.edu.

Funding

Yale Core Grant for Vision ResearchP30EY026878 · NEI · YALE UNIVERSITY · PI In-Jung Kim · 2016 to 2026
$7.1M
Inhibitory regulation of cortical visual processingR01EY022951 · NEI · YALE UNIVERSITY · PI CARDIN, JESSICA A · 2013 to 2025
$4.0M
GABAergic contributions to neural circuit deficits in schizophreniaR01MH102365 · NIMH · YALE UNIVERSITY · PI CARDIN, JESSICA A · 2014 to 2018
$2.1M
Role of GABAergic interneurons in developmental dysregulation of cortical functionR01MH113852 · NIMH · YALE UNIVERSITY · PI CARDIN, JESSICA A, HIGLEY, MICHAEL JAMES · 2017 to 2021
$2.1M
NEI NIH HHS P30 EY026878NEI NIH HHS R01 EY022951NIMH NIH HHS R01 MH102365NIMH NIH HHS R01 MH113852
6 · The paper itself

Abstract

Cortical networks receive a highly variable stream of inputs from internal and external influences, and must flexibly adapt their operations on a short timescale. Recent work has highlighted this state-dependent functional flexibility of cortical circuits and provided initial insights into underlying circuit-level mechanisms. Transitions from quiescent to aroused or task-engaged behavioral states are associated with common motifs of network activity, including changes in correlations and enhanced sensory encoding. Evidence points to a key role for selective activation of specific GABAergic interneuron populations in mediating mode-switching in cortical networks. Finally, inhibitory interneurons may function as a critical target for convergent state-dependent neuromodulatory sculpting of cortical circuits.

Indexed as

Interneurons

Identifiers

PMID31585330
PMCPMC6981226

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.