ArticleMolecular cell2019
Going in Circles: The Black Box of Circular RNA Immunogenicity.
Article in Molecular cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Review
- Circular RNA therapeutics: a new class of long-acting RNA medicines for oncology, immunology, and rare diseases.Frontiers in immunology · 2026Review
- miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities.Cells · 2023Review
- Review
- Viruses join the circular RNA world.The FEBS journal · 2021Review
- Circular RNAs: Expression, localization, and therapeutic potentials.Molecular therapy : the journal of the American Society of Gene Therapy · 2021Review
- Differential Expression Profiles and Functional Prediction of circRNAs in Necrotizing Enterocolitis.BioMed research international · 2021Article
- Hints From the Cellular Functions to the Practical Outlook of Circular RNAs.Frontiers in genetics · 2021Review
- Circular RNA as an Additional Player in the Conflicts Between the Host and the Virus.Frontiers in immunology · 2021Review
- The Biogenesis, Functions, and Roles of circRNAs in Bladder Cancer.Cancer management and research · 2020Review
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two recent papers in Molecular Cell (Chen et al., 2019; Wesselhoeft et al., 2019) have probed the putative immunogenicity of circular RNAs (circRNAs). These studies indicate that the stimulatory capacity of circRNAs depends on factors including the specific RNA, the mode of biogenesis, RNA modifications, cell type, and the means of delivery.
Indexed as
Identifiers
31585102What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.