Evidence map›Paper›PMID 31585070›Full record

ArticleThe American journal of pathology2020

Host Lymphotoxin-β Receptor Signaling Is Crucial for Angiogenesis of Metanephric Tissue Transplanted into Lymphoid Sites.

Maria Giovanna Francipane, Bing Han, Eric Lagasse

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Maria Giovanna FrancipaneMcGowan Institute for Regenerative Medicine and Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania; Ri.MED Foundation, Palermo, Italy. Electronic address: francipa@pitt.edu.
Bing HanMcGowan Institute for Regenerative Medicine and Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Eric LagasseMcGowan Institute for Regenerative Medicine and Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: lagasse@pitt.edu.
McGowan Institute for Regenerative Medicine · USUniversity of Pittsburgh · US

Funding

Organogenesis of Ectopic Tissue in Lymph NodeR01DK085711 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LAGASSE, ERIC · 2009 to 2013
$3.6M
A New Molecular Mechanism to Bioengineering a LiverR01DK114282 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LAGASSE, ERIC · 2018 to 2022
$2.1M
NIDDK NIH HHS R01 DK085711NIDDK NIH HHS R01 DK114282
6 · The paper itself

Abstract

The mouse lymph node (LN) can provide a niche to grow metanephric kidney to maturity. Here, we show that signaling through the lymphotoxin-β receptor (LTβR) is critical for kidney organogenesis both in the LN and the omentum. By transplanting kidney rudiments either in the LNs of mice undergoing LTβR antagonist treatment or in the omenta of Ltbr knockout (Ltbr

Indexed as

Neovascularization, PhysiologicOrganogenesisAnimalsEndothelial CellsKidney GlomerulusLymphoid TissueLymphotoxin beta ReceptorMiceMice, Inbred C57BLMice, KnockoutNF-kappaB-Inducing KinaseProtein Serine-Threonine KinasesRegenerationSignal TransductionLtbr protein, mouseLymphotoxin beta ReceptorNF-kappaB-Inducing KinaseProtein Serine-Threonine Kinases

Identifiers

PMID31585070
PMCPMC6943804
OpenAlexW2978961033

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.