ArticleAmerican journal of physiology. Heart and circulatory physiology2019
A 4D flow MRI evaluation of the impact of shear-dependent fluid viscosity on in vitro Fontan circulation flow.
Article in American journal of physiology. Heart and circulatory physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Case report of percutaneous intervention for extensive thrombosis after the Fontan procedure in a 14-year-old.European heart journal. Case reports · 2026Article
- Investigating the early diagnostic value of popliteal artery wall shear stress in lower extremity arterial disease in type 2 diabetes patients using color Doppler ultrasound combined with WSS quantitative analysis.Biomedical engineering online · 2026Article
- Significance of Reynolds Number Consistency in Non-Newtonian Hemodynamic Simulations: Insights from Fontan Circulation.Physics of fluids (Woodbury, N.Y. : 1994) · 2025Article
- Central Venous Waveform Patterns in the Fontan Circulation Independently Contribute to the Prediction of Composite Survival.Pediatric cardiology · 2024Review
- The impact of blood viscosity modeling on computational fluid dynamic simulations of pediatric patients with Fontan circulation.Physics of fluids (Woodbury, N.Y. : 1994) · 2024Article
- Exercise Performance: A Fontan Phenotype Predictive of Long-Term Survival.JACC. Advances · 2024Article
- In vitro hemodynamic performance of a blood pump for self-powered venous assist in univentricular hearts.Scientific reports · 2024Article
- Hemi-Fontan and bidirectional Glenn operations result in flow-mediated viscous energy loss at the time of stage II palliation.JTCVS open · 2023Article
- In Silico Evaluation of a Self-powered Venous Ejector Pump for Fontan Patients.Cardiovascular engineering and technology · 2023Article
- Hemodynamic characteristics in a cerebral aneurysm model using non-Newtonian blood analogues.Physics of fluids (Woodbury, N.Y. : 1994) · 2022Article
- Patient-Specific Inverse Modeling of In Vivo Cardiovascular Mechanics with Medical Image-Derived Kinematics as Input Data: Concepts, Methods, and Applications.Applied sciences (Basel, Switzerland) · 2022Article
- Is Doppler Echocardiography Adequate for Surgical Planning of Single Ventricle Patients?Cardiovascular engineering and technology · 2021Article
- Assessment of turbulent blood flow and wall shear stress in aortic coarctation using image-based simulations.Biomedical engineering online · 2021Article
- Diagnosis and Treatment of Right Heart Failure in Pulmonary Vascular Diseases: A National Heart, Lung, and Blood Institute Workshop.Circulation. Heart failure · 2021Review
- The Rheology of the Carotid Sinus: A Path Toward Bioinspired Intervention.Frontiers in bioengineering and biotechnology · 2021Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The Fontan procedure for univentricular heart defects creates a nonphysiologic circulation where systemic venous blood drains directly into the pulmonary arteries, leading to multiorgan dysfunction secondary to chronic low-shear nonpulsatile pulmonary blood flow and central venous hypertension. Although blood viscosity increases exponentially in this low-shear environment, the role of shear-dependent ("non-Newtonian") blood viscosity in this pathophysiology is unclear. We studied three-dimensional (3D)-printed Fontan models in an in vitro flow loop with a Philips 3-T magnetic resonance imaging (MRI) scanner. A 4D flow phase-contrast sequence was used to acquire a time-varying 3D velocity field for each experimental condition. On the basis of blood viscosity of a cohort of patients who had undergone the Fontan procedure, it was decided to use 0.04% xanthan gum as a non-Newtonian blood analog; 45% glycerol was used as a Newtonian control fluid. MRI data were analyzed using GTFlow and MATLAB software. The primary outcome, power loss, was significantly higher with the Newtonian fluid [14.8 (13.3, 16.4) vs. 8.1 (6.4, 9.8)%, medians with 95% confidence interval,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.