ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2020
Multiscale Dynamics of Spontaneous Brain Activity Is Associated With Walking Speed in Older Adults.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Effects of Repetitive Transcranial Magnetic Stimulation on Standing Balance and Walking in Older Adults with Age-related Neurological Disorders: A Systematic Review and Meta-analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Pooled it
- The comparison between effects of Taichi and conventional exercise on functional mobility and balance in healthy older adults: a systematic literature review and meta-analysis.Frontiers in public health · 2023Pooled it
- The Effects of Transcranial Direct Current Stimulation (tDCS) on Balance Control in Older Adults: A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2020Pooled it
- Targeted tDCS Mitigates Dual-Task Costs to Gait and Balance in Older Adults.Annals of neurology · 2021Trial
- Using Indoor Movement Complexity in Smart Homes to Detect Frailty in Older Adults: Multiple-Methods Case Series Study.JMIR aging · 2026Article
- Characterizing the relationship between functional network dynamics and the body mass index.Frontiers in nutrition · 2026Article
- The Physiologic Complexity of Prefrontal Oxygenation Dynamics Is Associated With Age and Executive Function: An Exploratory Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Effects of endurance exercise on physiologic complexity of the hemodynamics in prefrontal cortex.Neurophotonics · 2024Article
- Muscle activity variability patterns and stride to stride fluctuations of older adults are positively correlated during walking.Scientific reports · 2023Article
- The Multiscale Dynamics of Beat-to-Beat Blood Pressure Fluctuation Mediated the Relationship Between Frailty and Arterial Stiffness in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- The altered multiscale dynamics of spontaneous brain activity in depression with Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- A complex systems approach to aging biology.Nature aging · 2022Review
- The Multiscale Dynamics of Beat-to-Beat Blood Pressure Fluctuation Links to Functions in Older Adults.Frontiers in cardiovascular medicine · 2022Article
- Altered Brain Activity in Depression of Parkinson's Disease: A Meta-Analysis and Validation Study.Frontiers in aging neuroscience · 2022Article
- Sarcopenia and Neuroscience: Learning to Communicate.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Evidence for a Specific Association Between Sustained Attention and Gait Speed in Middle-to-Older-Aged Adults.Frontiers in aging neuroscience · 2021Article
- The Effects of Altitude-related Hypoxia Exposure on the Multiscale Dynamics of Blood Pressure Fluctuation During Sleep: The Observation from a Pilot Study.Nature and science of sleep · 2021Article
- The Complexity of Blood Pressure Fluctuation Mediated the Effects of Hypertension on Walking Speed in Older Adults.Frontiers in aging neuroscience · 2021Article
- Multiscale Dynamics of Blood Pressure Fluctuation Is Associated With White Matter Lesion Burden in Older Adults With and Without Hypertension: Observations From a Pilot Study.Frontiers in cardiovascular medicine · 2021Article
- Physical activity complexity, cognition, and risk of cognitive impairment and dementia in the Baltimore Longitudinal Study of Aging.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundIn older adults, compromised white matter tract integrity within the brain has been linked to impairments in mobility. We contend that poorer integrity disrupts mobility by altering the processing of sensorimotor and cognitive and attentional resources in neural networks. The richness of information processing in a given network can be quantified by calculating the complexity of resting-state functional MRI time series. We hypothesized that (i) older adults with lower brain complexity, specifically within sensorimotor, executive, and attention networks, would exhibit slower walking speed and greater dual-task costs (ie, dual-task cost) and (ii) such complexity would mediate the effect of white matter integrity on these metrics of mobility.
methodsFifty-three older adults completed a walking assessment and a neuroimaging protocol. Brain complexity was quantified by calculating the multiscale entropy of the resting-state functional MRI signal within seven previously defined functional networks. The white matter integrity across structures of the corpus callosum was quantified using fractional anisotropy.
resultsParticipants with lower resting-state complexity within the sensorimotor, executive, and attention networks walked more slowly under single- and dual-task (ie, walking while performing a serial-subtraction task) conditions (β > 0.28, p ≤ .01) and had a greater dual-task cost (β < -0.28, p < .04). Complexity in these networks mediated the influence of the corpus callosum genu on both single- (indirect effects > 0.15, 95% confidence intervals = 0.02-0.32) and dual-task walking speeds (indirect effects > 0.13, 95% confidence intervals = 0.02-0.33).
conclusionThese results suggest that the multiscale dynamics of resting-state brain activity correlate with mobility and mediate the effect of the microstructural integrity in the corpus callosum genu on walking speed in older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.