ArticlePloS one2019
Structural characterization of a novel polysaccharide from Sargassum thunbergii and its antioxidant and anti-inflammation effects.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 37 citations in OpenAlex.
- Dual-backbone pectic polysaccharide activates NOD1/RIPK2/NF-κB and mitochondrial metabolism to enhance the immune activity of macrophages.NPJ science of food · 2025Article
- Therapeutic and Nutraceutical Potential ofMarine drugs · 2025Review
- Genome Evolution of Two Intertidal Sargassum Species (S. fusiforme and S. thunbergii) and Their Response to Abiotic Stressors.Genome biology and evolution · 2025Article
- Evaluation of Bioactive Attributes and Emulsification Potential of Exopolysaccharide Produced by a Brown-rot Fungus Fomitopsis meliae AGDP-2.Applied biochemistry and biotechnology · 2023Article
- Relevance of the Extraction Stage on the Anti-Inflammatory Action of Fucoidans.Pharmaceutics · 2023Review
- Extraction optimization, structure features, and bioactivities of two polysaccharides from Corydalis decumbens.PloS one · 2023Article
- Sulfated Galactofucans: An Outstanding Class of Fucoidans with Promising Bioactivities.Marine drugs · 2022Review
- Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A Review.Marine drugs · 2021Review
- Fucoidan Characterization: Determination of Purity and Physicochemical and Chemical Properties.Marine drugs · 2020Review
- A Comprehensive and Comparative Analysis of the Fucoidan Compositional Data Across the Phaeophyceae.Frontiers in plant science · 2020Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel polysaccharide STSP-I was isolated and purified from Sargassum thunbergii. Its structure and bioactivity were studied using gas chromatography (GC), fourier transform infrared spectroscopy (FTIR), periodate oxidation-smith degradation, partial acid hydrolysis, methylation-GC-MS, nuclear magnetic resonance (NMR), transmission electron microscopy (TEM), radicals scavenging assays and anti-inflammatory assays. STSP-I was consisted of fucose and galactose with a molar ratio of 1.2:1, and its mass was 373 kDa. The main structural components of STSP-I were →4)-α-D-Galp-(1→ and →3)-β-L-Fucp-(1→, STSP-I was a non-branched polysaccharide, and TEM further revealed the existence of entangled chains and linear forms. Compared with Vitamin C (Vc), STSP-I showed a higher scavenging effect of superoxide radical (EC50 = 0.22 mg/mL) and an equivalent scavenging effect of hydroxyl radical (EC50 = 0.88 mg/mL). STSP-I also exhibited good inhibitory effects of TNF-α, IL-6 and COX-2 mRNA expressions in LPS-stimulated RAW 264.7 mouse macrophage cells, and the inhibitory effects were more than 91% at the concentrations of 75 and 150 μg/ml. The results indicate that the polysaccharide STSP-I from S. thunbergii with the linear structure may serve as potential antioxidant and anti-inflammatory agents.
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