Evidence map›Paper›PMID 31584893›Full record

ArticleEpidemiology (Cambridge, Mass.)2019

Posttraumatic Stress Disorder and Incident Infections: A Nationwide Cohort Study.

Tammy Jiang, Dóra Körmendiné Farkas, Thomas P Ahern, Timothy L Lash, Henrik T Sørensen, Jaimie L Gradus

Open access · goldAbstract read
In one paragraph

Article in Epidemiology (Cambridge, Mass.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  10. Does inflammation link stress to poor COVID-19 outcome?Stress and health : journal of the International Society for the Investigation of Stress · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Tammy JiangFrom the Department of Epidemiology, Boston University School of Public Health, Boston, MA.
Dóra Körmendiné FarkasDepartment of Clinical Epidemiology, Aarhus University, Aarhus N, Denmark.
Thomas P AhernDepartment of Surgery, Larner College of Medicine, University of Vermont, Burlington, VT.
Timothy L LashDepartment of Clinical Epidemiology, Aarhus University, Aarhus N, Denmark.
Henrik T SørensenFrom the Department of Epidemiology, Boston University School of Public Health, Boston, MA.
Jaimie L GradusFrom the Department of Epidemiology, Boston University School of Public Health, Boston, MA.
Aarhus University · DKBoston University · USEmory University · USUniversity of Vermont · US

Funding

Vermont Center on Behavior and HealthP20GM103644 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI KHADANGA, SHERRIE · 2013 to 2022
$21.3M
Characterizing Trauma Outcomes: From Pre-trauma Risk to Post-trauma SequelaeR01MH110453 · NIMH · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GRADUS, JAIMIE L. · 2017 to 2020
$1.3M
Constructing a Danish Reaction to Severe Stress CohortR21MH094551 · NIMH · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GRADUS, JAIMIE L. · 2012 to 2013
$321k
NIGMS NIH HHS P20 GM103644NIMH NIH HHS R01 MH110453NIMH NIH HHS R21 MH094551
6 · The paper itself

Abstract

backgroundIt is unknown whether posttraumatic stress disorder (PTSD) is associated with incident infections. This study's objectives were to examine (1) the association between PTSD diagnosis and 28 types of infections and (2) the interaction between PTSD diagnosis and sex on the rate of infections.

methodsThe study population consisted of a longitudinal nationwide cohort of all residents of Denmark who received a PTSD diagnosis between 1995 and 2011, and an age- and sex-matched general population comparison cohort. We fit Cox proportional hazards regression models to examine associations between PTSD diagnosis and infections. To account for multiple estimation, we adjusted the hazard ratios (HRs) using semi-Bayes shrinkage. We calculated interaction contrasts to assess the presence of interaction between PTSD diagnosis and sex.

resultsAfter semi-Bayes shrinkage, the HR for any type of infection was 1.8 (95% confidence interval: 1.6, 2.0), adjusting for marital status, non-psychiatric comorbidity, and diagnoses of substance abuse, substance dependence, and depression. The association between PTSD diagnosis and some infections (e.g., urinary tract infections) were stronger among women, whereas other associations were stronger among men (e.g., skin infections).

conclusionsThis study's findings suggest that PTSD diagnosis is a risk factor for numerous infection types and that the associations between PTSD diagnosis and infections are modified by sex.

Indexed as

AdolescentAdultAnxiety DisordersBacteremiaBayes TheoremCandidiasisCase-Control StudiesCohort StudiesDenmarkDepressive DisorderEye InfectionsFemaleGastroenteritisHepatitis, Viral, HumanHumansIncidence

Identifiers

PMID31584893
PMCPMC6779341
OpenAlexW2964795584

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.