ArticleEpidemiology (Cambridge, Mass.)2019
Perineal Talc Use, Douching, and the Risk of Uterine Cancer.
Article in Epidemiology (Cambridge, Mass.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Review
- Gaps in the usage and reporting of multiple imputation for incomplete data: findings from a scoping review of observational studies addressing causal questions.BMC medical research methodology · 2024Article
- Intimate Care Products and Incidence of Hormone-Related Cancers: A Quantitative Bias Analysis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Article
- Use of personal care product mixtures and incident hormone-sensitive cancers in the Sister Study: A U.S.-wide prospective cohort.Environment international · 2024Article
- Association of genital talc and douche use in early adolescence or adulthood with uterine fibroids diagnoses.American journal of obstetrics and gynecology · 2023Article
- Systematic review of the association between talc and female reproductive tract cancers.Frontiers in toxicology · 2023Review
- Examining differences in menstrual and intimate care product use by race/ethnicity and education among menstruating individuals.Frontiers in reproductive health · 2023Article
- Douching or Perineal Talc Use and Prevalent Fibroids in Young African American Women.Journal of women's health (2002) · 2021Article
- Talc, body powder, and ovarian cancer: A summary of the epidemiologic evidence.Gynecologic oncology · 2021Review
- The association between douching, genital talc use, and the risk of prevalent and incident cervical cancer.Scientific reports · 2021Article
- Genital powder use and risk of uterine cancer: A pooled analysis of prospective studies.International journal of cancer · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPerineal talc use and douching could affect the risk of uterine cancer through several possible pathways, including inflammation response, microbiota changes, or endocrine disruption. Two previous cohort studies of the association between talc use and uterine cancer have reported weak positive associations, but we know of no previous evaluations of the relationship between douching and uterine cancer.
methodsUsing a large prospective cohort, we examined the relationship between incident uterine cancer and self-reported use of talc or douche using Cox proportional hazards models.
resultsAfter excluding those with prior hysterectomy, 271 of 33,609 women reported incident uterine cancer (mean follow-up = 8.3 years in noncases; maximum 12.6 years). Overall, 26% of women reported ever using talc and 15% reported ever having douched. Ever talc use was associated with an increase in risk of uterine cancer (adjusted hazard ratio [HR] = 1.2; 95% confidence interval [CI] = 0.94, 1.6), with some evidence of a dose-response for frequency of talc use (P-for-trend = 0.07). Ever douching was not associated with uterine cancer risk (HR = 1.0; 95% CI = 0.72, 1.5), with no evidence of a frequency dose-response (P = 0.96). The estimates were similar when we restricted to invasive endometrial cancers, but not when we further restricted to endometroid adenocarcinomas.
conclusionThe positive association we observed between talc use and uterine cancer risk is consistent with findings from previous prospective cohort studies of endometrial cancer. The relationships between uterine cancer and both douching and talc use merit further consideration, particularly as both exposures are preventable.
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