Evidence map›Paper›PMID 31584877›Full record

ArticleAging2019

CircUBAP2-mediated competing endogenous RNA network modulates tumorigenesis in pancreatic adenocarcinoma.

Rongjie Zhao, Junjie Ni, Si Lu, Sujing Jiang, Liangkun You, Hao Liu, Jiawei Shou, Chongya Zhai, Wei Zhang, Shengpeng Shao and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Pooled it
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  4. [The function of circular RNA-microRNA-messenger RNA immune regulatory network in childhood allergic asthma].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
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  16. American journal of cancer research · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Rongjie ZhaoDepartment of Medical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, Zhejiang, China.
Junjie NiThe First Clinical College, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China.
Si LuThe Fourth Clinical College, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China.
Sujing JiangDepartment of Radiation and Medical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China.
Liangkun YouDepartment of Medical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, Zhejiang, China.
Hao LiuDepartment of Medical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, Zhejiang, China.
Jiawei ShouDepartment of Medical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, Zhejiang, China.
Chongya ZhaiDepartment of Medical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, Zhejiang, China.
Wei ZhangDepartment of Medical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, Zhejiang, China.
Shengpeng ShaoThe Second Clinical College, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China.
Xinmei YangDepartment of Oncology, The First Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang, China.
Hongming PanDepartment of Medical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, Zhejiang, China.
Weidong HanDepartment of Medical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, Zhejiang, China.
Sir Run Run Shaw Hospital · CNZhejiang Chinese Medical University · CNZhejiang University · CNFirst Affiliated Hospital of Wenzhou Medical University · CNFirst Hospital of Jiaxing · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the role of the competing endogenous RNA (ceRNA) network in the development and progression of pancreatic adenocarcinoma (PAAD). We analyzed the expression profiles of PAAD and normal pancreatic tissues from multiple GEO databases and identified 457 differentially expressed circular RNAs (DEcircRNAs), 19 microRNAs (DEmiRNAs) and 1993 mRNAs (DEmRNAs). We constructed a ceRNA network consisting of 4 DEcircRNAs, 3 DEmiRNAs and 149 DEmRNAs that regulates the NF-kappa B, PI3K-Akt, and Wnt signaling pathways. We then identified and validated five hub genes,

Indexed as

AdenocarcinomaPancreatic NeoplasmsTumor MicroenvironmentBiomarkers, TumorCarcinogenesisCarrier ProteinsCell Transformation, NeoplasticGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansRNA, Long NoncodingBiomarkers, TumorCarrier ProteinsRNA, Long NoncodingceRNAcircRNAimmune microenvironmentpancreatic adenocarcinoma

Identifiers

PMID31584877
PMCPMC6814619
OpenAlexW2978650120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.