Evidence map›Paper›PMID 31584617›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020

Healthcare Transition Outcomes Among Young Adults With Perinatally Acquired Human Immunodeficiency Virus Infection in the United States.

Katherine Tassiopoulos, Yanling Huo, Kunjal Patel, Deborah Kacanek, Susannah Allison, Suzanne Siminski, Sharon L Nichols, Claude A Mellins, Pediatric HIV/AIDS Cohort Study (PHACS)

Registry-linked trialAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02119702 (Adolescent Master Protocol for Participants 18 Years of Age and Older), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02119702 completednot on this map

Adolescent Master Protocol for Participants 18 Years of Age and Older (AMP Up)

TypeobservationalSponsorHarvard School of Public Health (HSPH)Ran2014 to 2025Enrolled818ConditionsHIV/AIDS
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Healthcare Transition From Pediatric to Adult Care Among Youth Living With HIV in South Carolina: Retrospective Study From 2005 to 2021.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2026
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Human Immunodeficiency Virus (HIV) Care Continuum Outcomes After Transition to Adult Care Among a Prospective Cohort of Youth With HIV in Atlanta, Georgia.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Observational
  13. Article
  14. Factors and Outcomes Associated With Viral Suppression Trajectory Group Membership Among Youth Transitioning From Pediatric to Adult HIV Care.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2022
    Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Katherine TassiopoulosDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Yanling HuoCenter for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Kunjal PatelDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Deborah KacanekCenter for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Susannah AllisonDivision of AIDS Research, National Institute of Mental Health, Bethesda, Maryland.
Suzanne SiminskiFrontier Science and Technology Research Foundation, Amherst, New York.
Sharon L NicholsDepartment of Neurosciences, University of California San Diego, La Jolla.
Claude A MellinsPsychiatry and Sociomedical Sciences, Columbia University, New York.
Pediatric HIV/AIDS Cohort Study (PHACS)

Funding

PHACS - Data and Operations CenterU01HD052102 · NICHD · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLIAMS, PAIGE L · 2005 to 2019
$242.7M
Pediatric HIV/AIDS Cohort Study (PHACS): Understanding Maternal HIV Disease through Pregnancy and the Postpartum Period and its Role in Child Health OutcomesU01HD052104 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI VAN DYKE, RUSSELL B. · 2005 to 2019
$15.7M
NICHD NIH HHS U01 HD052102NICHD NIH HHS U01 HD052104
6 · The paper itself

Abstract

backgroundYoung adults with perinatally acquired HIV (YPHIVs) living in the United States are transitioning to adult clinical care, yet there is little information on factors that affect transition outcomes.

methodsYPHIVs aged ≥18 years in the Pediatric HIV/AIDS Cohort Study (PHACS) AMP Up cohort approaching or having completed transition from pediatric to adult healthcare were included. Demographic and clinical characteristics and self-reported ability to self-manage healthcare were compared by transition status, and multivariable logistic regression models examined factors associated with satisfaction with, and retention in, adult clinical care (clinic visit within the previous 6 months).

resultsMost of the 455 YPHIVs, regardless of transition status, reported satisfaction with their clinic and care provider, but many reported antiretroviral medication nonadherence. Of the 124 YPHIVs who had transitioned, 56% had periods of unsuppressed HIV-1 RNA in the year before transition. Those who had transitioned were more likely to report high ability to self-manage their healthcare (ability to manage ≥7 of 8 skills) than those not transitioned. High self-management was associated with retention after transition (odds ratio, 3.40; 95% confidence interval, 1.33-9.12). Higher perceived emotional social support was also associated with retention. Older age at transition was associated with greater satisfaction with provider and clinic.

conclusionsYPHIVs have positive associations with their clinical care around the time of their transition to adult care, but unsuppressed viral load and suboptimal adherence are a concern. Strengthening skills that increase ability to self-manage care and enhance social support may increase retention in care and improve clinical health.

Indexed as

HIV InfectionsTransition to Adult CareAdolescentAdultAgedChildCohort StudiesHumansMedication AdherenceUnited StatesViral LoadYoung Adultadult healthcareperinatal HIV infectionself-managesocial supporttransition

Identifiers

PMID31584617
PMCPMC7312217

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.