ArticleJournal of hypertension2020
Central arterial stiffness and retinal vessel calibers: the Atherosclerosis Risk in Communities Study-Neurocognitive Study.
Article in Journal of hypertension, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Arterial stiffness measured by pulse wave velocity correlated with cognitive decline in hypertensive individuals: a systematic review.BMC neurology · 2024Pooled it
- Automated optical coherence tomography quantification of retinal wall-to-lumen alterations in preeclampsia.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Association of the apolipoproteins with retinal arteriosclerosis in a health examination population.Frontiers in cardiovascular medicine · 2026Article
- Risk factor patterns and vascular health in children with incident hypertension: The ExAMIN Youth SA study.Journal of human hypertension · 2025Article
- Correlation between atherogenic index of plasma and retinal vessels in the fundus: a cross-sectional study.European journal of medical research · 2025Article
- Association Between Pulse Wave Velocity and Cerebral Small Vessel Disease: A Scoping Review.Cureus · 2025Review
- Non-invasive real-time pulsed Doppler assessment of blood flow in mouse ophthalmic artery.Cell reports methods · 2025Article
- Standardization and clinical applications of retinal imaging biomarkers for cardiovascular disease: a Roadmap from an NHLBI workshop.Nature reviews. Cardiology · 2025Review
- ECG-gated retinal vessel calibre as a novel measure of aberrant pulsatile retinal flow in diabetes mellitus: a cross-sectional study.Journal of diabetes and metabolic disorders · 2024Article
- Atherosclerotic burden and cerebral small vessel disease: exploring the link through microvascular aging and cerebral microhemorrhages.GeroScience · 2024Review
- Quantifying ocular microcirculation in hypertension patients with carotid artery stenosis.Frontiers in neuroscience · 2024Article
- Comprehensive retinal vascular measurements: time in range is associated with peripheral retinal venular calibers in type 2 diabetes in China.Acta diabetologica · 2023Article
- Association of Central Retinal Arteriolar and Venular Equivalents with Brain-aging and Macular Ganglion Cell-inner Plexiform Layer Thickness.Ophthalmic epidemiology · 2023Article
- The role of retinal vessel geometry as an indicator of systemic arterial stiffness assessed by cardio-ankle vascular index.Frontiers in cardiovascular medicine · 2023Article
- Mid- to Late-Life Time-Averaged Cumulative Blood Pressure and Late-Life Retinal Microvasculature: The ARIC Study.Journal of the American Heart Association · 2022Article
- Impact of diabetic retinopathy on pulse wave analysis-derived arterial stiffness and hemodynamic parameters: A cross-sectional study from Gujarat, India.Indian journal of ophthalmology · 2021Article
- Carotid stiffness is associated with retinal microvascular dysfunction-The Maastricht study.Microcirculation (New York, N.Y. : 1994) · 2021Article
- Retinal capillary rarefaction is associated with arterial and kidney damage in hypertension.Scientific reports · 2021Article
- Aortic stiffness is associated with changes in retinal arteriole flow pulsatility mediated by local vasodilation in healthy young/middle-age adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
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Authors and funding
9 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundThe retinal microvasculature provides a window to the cerebral vasculature and enables examination of changes in retinal caliber that may mimic those occurring in cerebrovascular disease. The association of central arterial stiffness and retinal vessel caliber in a population sample is not fully understood.
methodsIn 1706 older adults (mean age 76.3, 58.1% women) from the population-based Atherosclerosis Risk in Communities Study, we examined the cross-sectional association of central arterial stiffness [carotid-femoral pulse wave velocity (cfPWV)] with retinal vessel calibers [central retinal arteriolar equivalent (CRAE) and central retinal vein equivalent (CRVE)]. We estimated the association of cfPWV with CRAE narrowing (<25th percentile) and CRVE widening (>75th percentile) after adjustment for age, sex, race-field center, BMI, smoking, and type 2 diabetes. We tested for effect modification by sex, hypertension, and type 2 diabetes.
resultsCarotid-femoral PWV (m/s) was not associated with the odds of CRAE narrowing [odds ratio (OR): 0.99; 95% CI: 0.95-1.03]. The association of cfPWV with CRVE widening was stronger in those without hypertension (OR: 1.10; 95% CI: 1.01-1.20) versus those with hypertension (OR: 1.01 95% CI: 0.96-1.05) and slightly stronger in those with type 2 diabetes (OR: 1.07; 95% CI: 1.00-1.14) versus without type 2 diabetes (OR: 1.01; 95% CI: 0.96-1.06).
conclusionsIn older adults, cfPWV was associated with wider retinal venular caliber, particularly in individuals without hypertension. Central arterial stiffening may be associated with cerebral microvascular changes, as exhibited in its retinal vasculature component.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.