ArticleEMBO reports2019
Apicomplexan F-actin is required for efficient nuclear entry during host cell invasion.
Article in EMBO reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- The human parasite, Toxoplasma gondii, is paralyzed without two components of the apical polar ring.PLoS pathogens · 2026Article
- Imaging malaria parasites across scales and time.Journal of microscopy · 2026Review
- Highly divergent apicomplexan cytoskeletons provide additional models for actin biology.The FEBS journal · 2025Review
- An apical ring protein essential for conoid complex assembly and daughter cell formation in Toxoplasma gondii.Nature communications · 2025Article
- Biological characteristics and epidemiological insights into the zoonotic potential of Colpodella spp.: a scoping review.Infectious diseases of poverty · 2025Article
- Adhesion-driven vesicle translocation through membrane-covered pores.Biophysical journal · 2025Article
- Architecture of theProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Gliding motility of the diatom Craspedostauros australis coincides with the intracellular movement of raphid-specific myosins.Communications biology · 2024Article
- The SUN-like protein TgSLP1 is essential for nuclear division in the apicomplexan parasite Toxoplasma gondii.Journal of cell science · 2023Article
- The cortical microtubules of Toxoplasma gondii underlie the helicity of parasite movement.Journal of cell science · 2023Article
- Plasmodium schizogony, a chronology of the parasite's cell cycle in the blood stage.PLoS pathogens · 2023Review
- Article
- Divergent Plasmodium actin residues are essential for filament localization, mosquito salivary gland invasion and malaria transmission.PLoS pathogens · 2022Article
- An apical protein, Pcr2, is required for persistent movement by the human parasite Toxoplasma gondii.PLoS pathogens · 2022Article
- A splitCas9 phenotypic screen in Toxoplasma gondii identifies proteins involved in host cell egress and invasion.Nature microbiology · 2022Article
- Ultrastructure of Myzocytosis and Cyst Formation, and the Role of Actin in Tubular Tether Formation inPathogens (Basel, Switzerland) · 2022Article
- Transcriptomics analysis of Toxoplasma gondii-infected mouse macrophages reveals coding and noncoding signatures in the presence and absence of MyD88.BMC genomics · 2021Article
- Actomyosin forces and the energetics of red blood cell invasion by the malaria parasite Plasmodium falciparum.PLoS pathogens · 2020Article
- Rab11A regulates dense granule transport and secretion during Toxoplasma gondii invasion of host cells and parasite replication.PLoS pathogens · 2020Article
- Apicomplexan F-actin is required for efficient nuclear entry during host cell invasion.EMBO reports · 2019Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 4 countries.
Funding
Abstract
The obligate intracellular parasites Toxoplasma gondii and Plasmodium spp. invade host cells by injecting a protein complex into the membrane of the targeted cell that bridges the two cells through the assembly of a ring-like junction. This circular junction stretches while the parasites apply a traction force to pass through, a step that typically concurs with transient constriction of the parasite body. Here we analyse F-actin dynamics during host cell invasion. Super-resolution microscopy and real-time imaging highlighted an F-actin pool at the apex of pre-invading parasite, an F-actin ring at the junction area during invasion but also networks of perinuclear and posteriorly localised F-actin. Mutant parasites with dysfunctional acto-myosin showed significant decrease of junctional and perinuclear F-actin and are coincidently affected in nuclear passage through the junction. We propose that the F-actin machinery eases nuclear passage by stabilising the junction and pushing the nucleus through the constriction. Our analysis suggests that the junction opposes resistance to the passage of the parasite's nucleus and provides the first evidence for a dual contribution of actin-forces during host cell invasion by apicomplexan parasites.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.