ReviewJournal of endocrinological investigation2020
Immunomodulatory effect of vitamin D and its potential role in the prevention and treatment of thyroid autoimmunity: a narrative review.
Review in Journal of endocrinological investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06304948 (The Link Between Human Cytomegalovirus Gene Expression and Glutamate Levels in Migraine), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Link Between Human Cytomegalovirus Gene Expression and Glutamate Levels in Migraine :Relationship to the Vit D Deficiency
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Serum 25-hydroxyvitamin D levels are associated with thyroid diseases: A systematic review and meta-analysis.Medicine · 2026Pooled it
- Association between serum vitamin D level and Graves' disease: a systematic review and meta-analysis.Nutrition journal · 2024Pooled it
- Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial.BMJ (Clinical research ed.) · 2022Trial
- Add-On Effect of Selenium and Vitamin D Combined Supplementation in Early Control of Graves' Disease Hyperthyroidism During Methimazole Treatment.Frontiers in endocrinology · 2022Trial
- Association between serum 25-hydroxyvitamin D levels and thyroid hormone profiles in Graves' disease: a retrospective cross-sectional stratified analysis.Nuclear medicine communications · 2026Article
- Vitamin D Receptor Polymorphisms and Immunological Effects of Vitamin D in Hashimoto's Thyroiditis.International journal of molecular sciences · 2025Review
- Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets.Frontiers in immunology · 2025Article
- Recent advances of trace elements in autoimmune thyroid disease.Frontiers in immunology · 2025Review
- Berberine Enhances Intestinal Mucosal Barrier Function by Promoting Vitamin D Receptor Activity.Chinese journal of integrative medicine · 2024Article
- Multifunctional nanoparticle-mediated combining therapy for human diseases.Signal transduction and targeted therapy · 2024Review
- Absence of a relationship between vitamin D and Graves' orbitopathy.Journal of endocrinological investigation · 2023Article
- Article
- How Does Vitamin D Affect Immune Cells Crosstalk in Autoimmune Diseases?International journal of molecular sciences · 2023Review
- Immunomodulatory role of vitamin D and selenium supplementation in newly diagnosed Graves' disease patients during methimazole treatment.Frontiers in endocrinology · 2023Article
- The Possible Role of Vitamin D and Autoimmunity in the Etiology of Obsessive-Compulsive Disorder.Alpha psychiatry · 2022Article
- Editorial: How can diet impair thyroid function?Frontiers in endocrinology · 2022Article
- Secondary prevention of fragility fractures: where do we stand during the COVID-19 pandemic?Journal of endocrinological investigation · 2021Article
- Observational
- Vitamin D, Chronic Migraine, and Extracranial Pain: Is There a Link? Data From an Observational Study.Frontiers in neurology · 2021Article
- Vitamin D, sport and health: a still unresolved clinical issue.Journal of endocrinological investigation · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The main role of vitamin D is to control mineral homeostasis. However, recent studies suggested the existence of a number of extraskeletal effects. Among the latter, preclinical studies provided consistent data on the involvement of vitamin D in innate and adaptive immunity and autoimmunity. Molecular biology studies showed that both vitamin D receptor and vitamin D enzymatic complexes are expressed in a large number of cells and tissues unrelated to mineral homeostasis. In contrast, only a few randomized clinical trials in humans investigated the possible role of vitamin D in the prevention or treatment of immunological disorders. In this regard, low serum vitamin D levels have been reported in observational trials in human autoimmune disorders. The aim of the present paper was to review the potential implications of vitamin D in immune modulation, with special focus on thyroid autoimmune disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.