Evidence map›Paper›PMID 31584137›Full record

ArticleDigestive diseases and sciences2020

A20 Restores Impaired Intestinal Permeability and Inhibits Th2 Response in Mice with Colitis.

Donghui Chen, Li Ma, Tianyong Hu, Jiangqi Liu, Baohui Chen, Pingchang Yang, Zhiqiang Liu

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In one paragraph

Article in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Nutrients · 2023
    Article
  3. Review
  4. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Donghui ChenChildren's Hospital Affiliated to Zhengzhou University, Zhengzhou, 457000, China.
Li MaLonggang ENT Hospital, Institute of ENT, Shenzhen Key Laboratory of ENT, No. 3004, Longgang Avenue, Longgang District, Shenzhen, 518172, China.
Tianyong HuLonggang ENT Hospital, Institute of ENT, Shenzhen Key Laboratory of ENT, No. 3004, Longgang Avenue, Longgang District, Shenzhen, 518172, China.
Jiangqi LiuLonggang ENT Hospital, Institute of ENT, Shenzhen Key Laboratory of ENT, No. 3004, Longgang Avenue, Longgang District, Shenzhen, 518172, China.
Baohui ChenLonggang ENT Hospital, Institute of ENT, Shenzhen Key Laboratory of ENT, No. 3004, Longgang Avenue, Longgang District, Shenzhen, 518172, China.
Pingchang YangState Key Laboratory of Respiratory Disease for Allergy, Shenzhen University School of Medicine, Shenzhen University, Shenzhen, 518061, China.
Zhiqiang LiuLonggang ENT Hospital, Institute of ENT, Shenzhen Key Laboratory of ENT, No. 3004, Longgang Avenue, Longgang District, Shenzhen, 518172, China. liuzhiqiang05312438@126.com.ORCID 0000-0003-1140-3924
Longgang Central Hospital · CNShenzhen University · CNZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsThe etiology of inflammatory bowel disease is multifactorial and still obscure. The protective role of ubiquitin E3 ligase A20 (A20) in colitis needs to be further elucidated. This study aimed to investigate whether A20 exogenous administration restored impaired intestinal permeability and inhibited T helper (Th)2 response in mice with colitis.

methodsThe effect of A20 overexpression in colonic mucosa on epithelial barrier function and T cell differentiation was evaluated in mice with dextran sulfate sodium (DSS)-induced chronic colitis.

resultsA20 rectal treatment alleviated DSS-induced chronic colitis and restored impaired intestinal permeability. Oral challenge with 2% DSS elicited a Th2-type response in mice with colitis, and A20 rectal treatment inhibited CD4

conclusionA20 rectal treatment restores impaired intestinal permeability and inhibits activated Th2 cell response in mice with colitis.

Indexed as

AnimalsColitisColonDextran SulfateIntestinal MucosaMiceMice, Inbred C57BLPermeabilityTh2 CellsTumor Necrosis Factor alpha-Induced Protein 3Dextran SulfateTnfaip3 protein, mouseTumor Necrosis Factor alpha-Induced Protein 3A20ColitisInflammatory bowel diseaseIntestinal permeabilityTh2 cells

Identifiers

PMID31584137
OpenAlexW2978448251

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.