Evidence map›Paper›PMID 31584094›Full record

ArticleThe Journal of infectious diseases2020

Effect of Seasonal Malaria Chemoprevention on Immune Markers of Exhaustion and Regulation.

Oumar Attaher, Irfan Zaidi, Jennifer L Kwan, Djibrilla Issiaka, Mamoudou B Samassekou, Kadidia B Cisse, Barou Coulibaly, Sekouba Keita, Sibiri Sissoko, Tiangoua Traore and 9 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02504918 (Markers of T Cell Suppression), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02504918 completednot on this map

Markers of T Cell Suppression: Associations With Malaria Infection and Antimalarial Treatment

TypeobservationalSponsorNational Institute of Allergy and Infectious Diseases (NIAID)Ran2015 to 2018Enrolled200ConditionsMalaria
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 2 countries.

Oumar AttaherMalaria Research and Training Center, University of Sciences, Techniques, and Technology of Bamako, Bamako, Mali.
Irfan ZaidiLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Jennifer L KwanLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Djibrilla IssiakaMalaria Research and Training Center, University of Sciences, Techniques, and Technology of Bamako, Bamako, Mali.
Mamoudou B SamassekouMalaria Research and Training Center, University of Sciences, Techniques, and Technology of Bamako, Bamako, Mali.
Kadidia B CisseMalaria Research and Training Center, University of Sciences, Techniques, and Technology of Bamako, Bamako, Mali.
Barou CoulibalyMalaria Research and Training Center, University of Sciences, Techniques, and Technology of Bamako, Bamako, Mali.
Sekouba KeitaMalaria Research and Training Center, University of Sciences, Techniques, and Technology of Bamako, Bamako, Mali.
Sibiri SissokoMalaria Research and Training Center, University of Sciences, Techniques, and Technology of Bamako, Bamako, Mali.
Tiangoua TraoreMalaria Research and Training Center, University of Sciences, Techniques, and Technology of Bamako, Bamako, Mali.
Kalifa DiarraMalaria Research and Training Center, University of Sciences, Techniques, and Technology of Bamako, Bamako, Mali.
Bacary S DiarraMalaria Research and Training Center, University of Sciences, Techniques, and Technology of Bamako, Bamako, Mali.
Adama DembeleMalaria Research and Training Center, University of Sciences, Techniques, and Technology of Bamako, Bamako, Mali.
Moussa B KanouteMalaria Research and Training Center, University of Sciences, Techniques, and Technology of Bamako, Bamako, Mali.
Almahamoudou MahamarMalaria Research and Training Center, University of Sciences, Techniques, and Technology of Bamako, Bamako, Mali.
Amadou BarryMalaria Research and Training Center, University of Sciences, Techniques, and Technology of Bamako, Bamako, Mali.
Michal FriedLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Alassane DickoMalaria Research and Training Center, University of Sciences, Techniques, and Technology of Bamako, Bamako, Mali.
Patrick E DuffyLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
University of Bamako · MLNational Institute of Allergy and Infectious Diseases · USNational Institutes of Health · US

Funding

The Role of T Cell Regulatory Mechanisms in Protection from Severe MalariaZIAAI001147 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DUFFY, PATRICK · 2011 to 2025
$2.3M
Intramural NIH HHS ZIA AI001147
6 · The paper itself

Abstract

backgroundSeasonal malaria chemoprevention (SMC) is a novel strategy to reduce malaria infections in children. Infection with Plasmodium falciparum results in immune dysfunction characterized by elevated expression of markers associated with exhaustion, such as PD1 and LAG3, and regulatory CD4+FOXP3+ T cells.

methodsIn the current study, the impact of seasonal malaria chemoprevention on malaria-induced immune dysfunction, as measured by markers associated with exhaustion and regulatory T cells, was explored by flow cytometry.

resultsChildren that received seasonal malaria chemoprevention had fewer malaria episodes and showed significantly lower fold changes in CD4+PD1+ and CD4+PD1+LAG3+ compared to those that did not receive SMC. Seasonal malaria chemoprevention had no observable effect on fold changes in CD8 T cells expressing PD1 or CD160. However, children receiving SMC showed greater increases in CD4+FOXP3+ T regulatory cells compared to children not receiving SMC.

conclusionsThese results provide important insights into the dynamics of malaria-induced changes in the CD4 T-cell compartment of the immune system and suggest that the reduction of infections due to seasonal malaria chemoprevention may also prevent immune dysfunction. CLINICAL TRIALS REGISTRATION: NCT02504918.

Indexed as

AmodiaquineAntigens, CDAntimalarialsBiomarkersCD4-Positive T-LymphocytesChild, PreschoolDrug CombinationsFemaleForkhead Transcription FactorsHumansInfantLymphocyte Activation Gene 3 ProteinMalaria, FalciparumMaleProgrammed Cell Death 1 ReceptorPyrimethamineAmodiaquineAntigens, CDAntimalarialsBiomarkersDrug Combinationsfanasil, pyrimethamine drug combinationForkhead Transcription FactorsFOXP3 protein, humanLag3 protein, humanLymphocyte Activation Gene 3 ProteinPDCD1 protein, humanProgrammed Cell Death 1 ReceptorPyrimethamineSulfadoxineimmune dysfunctionseasonal malaria chemopreventionT-cell exhaustionT-cell regulation

Identifiers

PMID31584094
PMCPMC6910875
OpenAlexW2978365290

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.