Evidence map›Paper›PMID 31584046›Full record

ArticleChemical communications (Cambridge, England)2019

Single photon DNA photocleavage at 830 nm by quinoline dicarbocyanine dyes.

Kanchan Basnet, Tayebeh Fatemipouya, Anna St Lorenz, Mindy Nguyen, Oleh Taratula, Maged Henary, Kathryn B Grant

Open access · greenAbstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Synthesis of 2-Amino-Molecules (Basel, Switzerland) · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kanchan BasnetDepartment of Chemistry, Georgia State University, Atlanta, GA 30303, USA. kbgrant@gsu.edu mhenary1@gsu.edu.
Tayebeh FatemipouyaDepartment of Chemistry, Georgia State University, Atlanta, GA 30303, USA. kbgrant@gsu.edu mhenary1@gsu.edu.
Anna St LorenzDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, USA.
Mindy NguyenDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, USA.
Oleh TaratulaDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, USA.
Maged HenaryDepartment of Chemistry, Georgia State University, Atlanta, GA 30303, USA. kbgrant@gsu.edu mhenary1@gsu.edu and Center for Diagnostics and Therapeutics, Atlanta, GA 30303, USA.ORCID http://orcid.org/0000-0002-6475-0156
Kathryn B GrantDepartment of Chemistry, Georgia State University, Atlanta, GA 30303, USA. kbgrant@gsu.edu mhenary1@gsu.edu.ORCID http://orcid.org/0000-0002-4666-799X
Georgia State University · USOregon State University · US

Funding

Image-Guided Drug Delivery for Pancreatic Neuroendocrine Tumor.R01EB022230 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI CHOI, HAK SOO, HENARY, MAGED M · 2017 to 2020
$3.6M
Novel Nanomedicine-Based Therapeutic Approach For Treatment of Cancer CachexiaR37CA234006 · NCI · OREGON STATE UNIVERSITY · PI TARATULA, OLEH · 2019 to 2025
$3.2M
NCI NIH HHS R37 CA234006NIBIB NIH HHS R01 EB022230
6 · The paper itself

Abstract

We have synthesized symmetrical carbocyanine dyes in which two 4-quinolinium rings are joined by a pentamethine bridge that is meso-substituted with H or Cl. Irradiation of the halogenated dye at 830 nm produces hydroxyl radicals that generate DNA direct strand breaks. This represents the first reported example of DNA photocleavage upon single photon excitation of a chromophore at wavelengths above 800 nm.

Indexed as

Antineoplastic AgentsCarbocyaninesCell Line, TumorCell SurvivalDNADNA CleavageFluorescent DyesHumansHydroxyl RadicalInfrared RaysMolecular StructureOptical ImagingPhotochemical ProcessesPhotonsQuinolinesSpectrometry, FluorescenceAntineoplastic AgentsCarbocyaninesDNAFluorescent DyesHydroxyl RadicalQuinolines

Identifiers

PMID31584046
PMCPMC6953408
OpenAlexW2975697787

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.