Evidence map›Paper›PMID 31583936›Full record

ArticleJournal of the American Heart Association2019

Endothelial Function Assessed by Digital Volume Plethysmography Predicts the Development and Progression of Type 2 Diabetes Mellitus.

Omar Hahad, Philipp S Wild, Jürgen H Prochaska, Andreas Schulz, Iris Hermanns, Karl J Lackner, Norbert Pfeiffer, Irene Schmidtmann, Manfred Beutel, Tommaso Gori and 2 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Autonomic cardiovascular changes during reactive hyperemia.Clinical physiology and functional imaging · 2026
    Article
  6. Article
  7. Tinnitus is not associated with cardiovascular risk factors or mortality in the Gutenberg Health Study.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Vascular function: a key player in hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study.Clinical research in cardiology : official journal of the German Cardiac Society · 2022
    Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Omar HahadCenter for Cardiology-Cardiology I University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
Philipp S WildPreventive Cardiology and Preventive Medicine Center for Cardiology University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
Jürgen H ProchaskaPreventive Cardiology and Preventive Medicine Center for Cardiology University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
Andreas SchulzPreventive Cardiology and Preventive Medicine Center for Cardiology University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
Iris HermannsPreventive Cardiology and Preventive Medicine Center for Cardiology University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
Karl J LacknerGerman Center for Cardiovascular Research partner site Rhine-Main Mainz Germany.
Norbert PfeifferDepartment of Ophthalmology University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
Irene SchmidtmannInstitute of Medical Biostatistics, Epidemiology and Informatics University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
Manfred BeutelDepartment of Psychosomatic Medicine and Psychotherapy University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
Tommaso GoriCenter for Cardiology-Cardiology I University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
John E DeanfieldInstitute of Cardiovascular Science University College London London United Kingdom.
Thomas MünzelCenter for Cardiology-Cardiology I University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
Johannes Gutenberg University Mainz · DEUniversity Medical Center of the Johannes Gutenberg University Mainz · DEGerman Centre for Cardiovascular Research · DEUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Endothelial dysfunction is a consequence of type 2 diabetes mellitus, but it is unclear whether endothelial dysfunction of conductance versus resistance vessels may also precede type 2 diabetes mellitus development. Methods and Results In a population-based cohort of 15 010 individuals from the GHS (Gutenberg Health Study) (aged 35-74 years at enrollment in 2007-2012), we identified 1610 cases of incident pre-diabetes mellitus and 386 cases of incident type 2 diabetes mellitus by hemoglobin A

Indexed as

AdultAgedDiabetes Mellitus, Type 2Disease ProgressionEndothelium, VascularFemaleFingersHumansMaleMiddle AgedPlethysmographyRetrospective StudiesVasodilationdigital volume plethysmographyendothelial dysfunctionflow‐mediated dilationpopulation basedrisk of type 2 diabetes mellitus

Identifiers

PMID31583936
PMCPMC6818038
OpenAlexW2978742802

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.