Evidence map›Paper›PMID 31583882›Full record

ArticleACS infectious diseases2019

Identification of Four Amoebicidal Nontoxic Compounds by a Molecular Docking Screen of

Da Shi, Kirti Kandhwal Chahal, Patricia Oto, Louis-Felix Nothias, Anjan Debnath, James H McKerrow, Larissa M Podust, Ruben Abagyan

Abstract read
In one paragraph

Article in ACS infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Miconazole-like Scaffold is a Promising Lead forJournal of medicinal chemistry · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Da ShiSkaggs School of Pharmacy and Pharmaceutical Science , University of California, San Diego , 9500 Gilman Drive , La Jolla , California 92093 , United States.ORCID 0000-0002-1953-2299
Kirti Kandhwal ChahalSkaggs School of Pharmacy and Pharmaceutical Science , University of California, San Diego , 9500 Gilman Drive , La Jolla , California 92093 , United States.
Patricia OtoSkaggs School of Pharmacy and Pharmaceutical Science , University of California, San Diego , 9500 Gilman Drive , La Jolla , California 92093 , United States.
Louis-Felix NothiasSkaggs School of Pharmacy and Pharmaceutical Science , University of California, San Diego , 9500 Gilman Drive , La Jolla , California 92093 , United States.
Anjan DebnathSkaggs School of Pharmacy and Pharmaceutical Science , University of California, San Diego , 9500 Gilman Drive , La Jolla , California 92093 , United States.
James H McKerrowSkaggs School of Pharmacy and Pharmaceutical Science , University of California, San Diego , 9500 Gilman Drive , La Jolla , California 92093 , United States.
Larissa M PodustSkaggs School of Pharmacy and Pharmaceutical Science , University of California, San Diego , 9500 Gilman Drive , La Jolla , California 92093 , United States.
Ruben AbagyanSkaggs School of Pharmacy and Pharmaceutical Science , University of California, San Diego , 9500 Gilman Drive , La Jolla , California 92093 , United States.ORCID 0000-0001-9309-2976
University of California San Diego · USGuru Jambheshwar University of Science and Technology · IN

Funding

UC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4M
Addressing biomedical challenges with computational mechanics and big dataR35GM131881 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ABAGYAN, RUBEN · 2019 to 2023
$1.9M
Brain Penetrant Microtubule-Stabilizers to treat CNS-invasive parasitic diseasesR21AI133394 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BALLATORE, CARLO, CAFFREY, CONOR · 2018 to 2019
$426k
NCATS NIH HHS KL2 TR001444NIAID NIH HHS R21 AI133394NIGMS NIH HHS R35 GM131881
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AmebicidesDose-Response Relationship, DrugHEK293 CellsHumansIsomerasesModels, MolecularMolecular Docking SimulationNaegleria fowleriPhenotypeProtein ConformationSequence HomologySmall Molecule LibrariesAmebicidesIsomerasesSmall Molecule Librariesdrug discoveryhomology modelingNaegleria fowleriprimary amoebic meningoencephalitisvirtual ligand screen

Identifiers

PMID31583882
PMCPMC7085920
OpenAlexW2978442899

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.