Evidence map›Paper›PMID 31583825›Full record

ReviewInfluenza and other respiratory viruses2019

Improving immunological insights into the ferret model of human viral infectious disease.

Julius Wong, Daniel Layton, Adam K Wheatley, Stephen J Kent

Open access · goldAbstract readReview
In one paragraph

Review in Influenza and other respiratory viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Experimental Infection of Ferrets withPathogens (Basel, Switzerland) · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. A Single-Dose Intranasal Combination Panebolavirus Vaccine.The Journal of infectious diseases · 2023
    Article
  12. Review
  13. Ferrets: A powerful model of SARS-CoV-2.Zoological research · 2023
    Review
  14. Article
  15. Article
  16. The immune system of the ferret (Veterinarni medicina · 2022
    Review
  17. Ferrets as a model for tuberculosis transmission.Frontiers in cellular and infection microbiology · 2022
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Julius WongDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Vic., Australia.ORCID 0000-0003-0253-6151
Daniel LaytonCSIRO Health and Biosecurity, Australian Animal Health Laboratories, Geelong, Vic., Australia.
Adam K WheatleyDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Vic., Australia.ORCID 0000-0002-5593-9387
Stephen J KentDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Vic., Australia.ORCID 0000-0002-8539-4891
The University of Melbourne · AUAustralian Centre for Disease Preparedness · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferrets are a well-established model for studying both the pathogenesis and transmission of human respiratory viruses and evaluation of antiviral vaccines. Advanced immunological studies would add substantial value to the ferret models of disease but are hindered by the low number of ferret-reactive reagents available for flow cytometry and immunohistochemistry. Nevertheless, progress has been made to understand immune responses in the ferret model with a limited set of ferret-specific reagents and assays. This review examines current immunological insights gained from the ferret model across relevant human respiratory diseases, with a focus on influenza viruses. We highlight key knowledge gaps that need to be bridged to advance the utility of ferrets for immunological studies.

Indexed as

Disease Models, AnimalAnimalsFerretsHumansImmunityInfluenza, HumanInfluenza VaccinesOrthomyxoviridaeOrthomyxoviridae InfectionsVirus DiseasesInfluenza Vaccinesferretimmunologyinfluenza

Identifiers

PMID31583825
PMCPMC6800307
OpenAlexW2977646961

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.