ArticleEuropean journal of immunology2020
Rapid thymectomy of NSG mice to analyze the role of native and grafted thymi in humanized mice.
Article in European journal of immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Modeling immune responses to autologous and allogeneic human stem cell-derived islet grafts in vivo.JCI insight · 2026Article
- Transgenic expression of human CD47 on pig cells provides only partial protection against human macrophage-mediated destruction in human immune system mice.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Article
- A universal platform for simultaneous TCRα/β removal enables safer and more potent TCR therapies and autoimmune modeling.bioRxiv : the preprint server for biology · 2026Article
- Neonatal and pediatric thymic grafts generate similar human T-cell chimerism in humanized mice.Frontiers in immunology · 2026Article
- Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice.eLife · 2025Article
- T Cell Development and Responses in Human Immune System Mice.Annual review of immunology · 2025Review
- Pathophysiology and preclinical relevance of experimental graft-versus-host disease in humanized mice.Biomarker research · 2024Review
- Efficient generation of human immune system rats using human CD34Stem cell reports · 2024Article
- Review
- Complete remission of diabetes with a transient HDAC inhibitor and insulin in streptozotocin mice.Communications biology · 2023Article
- Origin, phenotype and autoimmune potential of T cells in human immune system mice receiving neonatal human thymus tissue.Frontiers in immunology · 2023Article
- Towards gene therapy for IPEX syndrome.European journal of immunology · 2022Review
- Human stem cell-derived thymic epithelial cells enhance human T-cell development in a xenogeneic thymus.The Journal of allergy and clinical immunology · 2022Article
- Defects in Long-Term APC Repopulation Ability of Adult Human Bone Marrow Hematopoietic Stem Cells (HSCs) Compared with Fetal Liver HSCs.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Modeling human T1D-associated autoimmune processes.Molecular metabolism · 2022Review
- Role of the thymus in spontaneous development of a multi-organ autoimmune disease in human immune system mice.Journal of autoimmunity · 2021Article
- High Throughput Human T Cell Receptor Sequencing: A New Window Into Repertoire Establishment and Alloreactivity.Frontiers in immunology · 2021Review
- Humanized Mouse Models for Evaluation of PSC Immunogenicity.Current protocols in stem cell biology · 2020Review
- Reduced positive selection of a human TCR in a swine thymus using a humanized mouse model for xenotolerance induction.Xenotransplantation · 2020Article
- Negative selection of human T cells recognizing a naturally-expressed tissue-restricted antigen in the human thymus.Journal of translational autoimmunity · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We developed a rapid method to remove the native mouse thymus from NSG mice, which allowed us to compare the behavior of human immune cells in the presence or absence of human T cells in human immune system mice. Removing the native mouse thymus is critical for studies of human thymopiesis in grafted thymic tissue in humanized mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.