Evidence map›Paper›PMID 31583589›Full record

ReviewAdvances in experimental medicine and biology2019

Neuroglia in Ageing.

Alexei Verkhratsky, Robert Zorec, Jose Julio Rodriguez-Arellano, Vladimir Parpura

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Article
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  13. Article
  14. Neuroprotective Metabolites ofInternational journal of molecular sciences · 2021
    Article
  15. Review
  16. Review
  17. Article
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  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexei VerkhratskyFaculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK. Alexej.Verkhratsky@manchester.ac.uk.
Robert ZorecLaboratory of Neuroendocrinology-Molecular Cell Physiology, Faculty of Medicine, Institute of Pathophysiology, University of Ljubljana, Ljubljana, Slovenia.
Jose Julio Rodriguez-ArellanoAchucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, 48011, Bilbao, Spain.
Vladimir ParpuraDepartment of Neurobiology, The University of Alabama at Birmingham, Birmingham, AL, USA.

Funding

Connexin 43 Modulates Regulated ExocytosisR01GM123971 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GRAY, MICHELLE · 2019 to 2022
$1.3M
NIGMS NIH HHS R01 GM123971
6 · The paper itself

Abstract

Ageing reduces the functional capacity of all organs, so does that of the nervous system; the latter is evident in the reduction of cognitive abilities, learning and memory. While the exact mechanisms of ageing of the nervous system remain elusive, it is without doubt that morpho-functional changes in a variety of neuroglial cells contribute to this process. The age-dependent changes in neuroglia are characterised by a progressive loss of function. This reduces glial ability to homeostatically nurture, protect and regenerate the nervous tissue. Such neuroglial paralysis also facilitates neurodegenerative processes. Ageing of neuroglia is variable and can be affected by environmental factors and comorbidities.

Indexed as

AgingHumansNeurogliaAgeingAstrocyteMicrogliaNG2 cellsOligodendrocytes

Identifiers

PMID31583589
PMCPMC7188603

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.