Evidence map›Paper›PMID 31583584›Full record

ReviewAdvances in experimental medicine and biology2019

Physiology of Astroglia.

Alexei Verkhratsky, Vladimir Parpura, Nina Vardjan, Robert Zorec

Open access · greenAbstract readReview
In one paragraph

Review in Advances in experimental medicine and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
59.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 303 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Quantification of monoamine oxidase B expression withEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Yin Yang 1: Function, Mechanisms, and Glia.Neurochemical research · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
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  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Alexei VerkhratskyFaculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK. Alexej.Verkhratsky@manchester.ac.uk.
Vladimir ParpuraDepartment of Neurobiology, The University of Alabama at Birmingham, Birmingham, AL, USA.
Nina VardjanLaboratory of Neuroendocrinology-Molecular Cell Physiology, Faculty of Medicine, Institute of Pathophysiology, University of Ljubljana, Ljubljana, Slovenia.
Robert ZorecLaboratory of Neuroendocrinology-Molecular Cell Physiology, Faculty of Medicine, Institute of Pathophysiology, University of Ljubljana, Ljubljana, Slovenia.
Celica (Slovenia) · SIUniversity of Alabama at Birmingham · USUniversity of Ljubljana · SIUniversity of Manchester · GB

Funding

Connexin 43 Modulates Regulated ExocytosisR01GM123971 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GRAY, MICHELLE · 2019 to 2022
$1.3M
NIGMS NIH HHS R01 GM123971
6 · The paper itself

Abstract

Astrocytes are principal cells responsible for maintaining the brain homeostasis. Additionally, these glial cells are also involved in homocellular (astrocyte-astrocyte) and heterocellular (astrocyte-other cell types) signalling and metabolism. These astroglial functions require an expression of the assortment of molecules, be that transporters or pumps, to maintain ion concentration gradients across the plasmalemma and the membrane of the endoplasmic reticulum. Astrocytes sense and balance their neurochemical environment via variety of transmitter receptors and transporters. As they are electrically non-excitable, astrocytes display intracellular calcium and sodium fluctuations, which are not only used for operative signalling but can also affect metabolism. In this chapter we discuss the molecules that achieve ionic gradients and underlie astrocyte signalling.

Indexed as

Signal TransductionAstrocytesBrainCalciumHomeostasisHumansIon PumpsNeurogliaReceptors, NeurotransmitterSodiumCalciumIon PumpsReceptors, NeurotransmitterSodiumAstrocytesBrain homoeostasisCa2+ signallingIon channelsNa+ signallingNeurotransmitter receptorsSLC transporters

Identifiers

PMID31583584
PMCPMC7265998
OpenAlexW2984108676

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.