Evidence map›Paper›PMID 31583582›Full record

ReviewAdvances in experimental medicine and biology2019

The Concept of Neuroglia.

Alexei Verkhratsky, Margaret S Ho, Robert Zorec, Vladimir Parpura

Abstract readReview
In one paragraph

Review in Advances in experimental medicine and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Review
  3. Glial Cells and Aging: From the CNS to the Cerebellum.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Review
  6. Functions of Astrocytes under Normal Conditions and after a Brain Disease.International journal of molecular sciences · 2023
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. β-micrustoxin (Mlx-9), a PLAThe journal of venomous animals and toxins including tropical diseases · 2022
    Article
  15. Review
  16. Application of Graphene in Tissue Engineering of the Nervous System.International journal of molecular sciences · 2021
    Review
  17. Article
  18. Review
  19. Neuroglia in Psychiatric Disorders.Advances in neurobiology · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexei VerkhratskyFaculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK. Alexej.Verkhratsky@manchester.ac.uk.
Margaret S HoSchool of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Robert ZorecLaboratory of Neuroendocrinology-Molecular Cell Physiology, Faculty of Medicine, Institute of Pathophysiology, University of Ljubljana, Ljubljana, Slovenia.
Vladimir ParpuraDepartment of Neurobiology, The University of Alabama at Birmingham, Birmingham, AL, USA.

Funding

Connexin 43 Modulates Regulated ExocytosisR01GM123971 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GRAY, MICHELLE · 2019 to 2022
$1.3M
NIGMS NIH HHS R01 GM123971
6 · The paper itself

Abstract

Neuroglia represent a diverse population of non-neuronal cells in the nervous systems, be that peripheral, central, enteric or autonomic nervous system. Arguably, these cells represent about half of the volume of the human brain. This volumetric ratio, and by extension glia to neurone ratio, not only widely differ depending on the size of the animal species brain and its positioning on the phylogenetic tree, but also vary between the regions of an individual brain. Neuroglia derived from a dual origin (ectoderm and mesodermal) and in an assorted morphology, yet their functional traits can be mainly classified into being keepers of homeostasis (water, ions, neurotransmitters, metabolites, fuels, etc.) and defenders (e.g., against microbial organisms, etc.) of the nervous system. As these capabilities go awry, neuroglia ultimately define their fundamental role in most, if not, all neuropathologies. This concept presented in this chapter serves as a general introduction into the world of neuroglia and subsequent topics covered by this book.

Indexed as

AnimalsHomeostasisHumansNeurogliaNeuronsNeurotransmitter AgentsPhylogenyNeurotransmitter AgentsDefenceFunctionHomeostasisMorphologyNeurogliaOriginPathophysiologyPhysiology

Identifiers

PMID31583582
PMCPMC7188601

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.