Evidence map›Paper›PMID 31583562›Full record

ArticleMolecular biology reports2020

Interacting adipose-derived stem cells and microvascular endothelial cells provide a beneficial milieu for soft tissue healing.

Sophie Bachmann, Martina Jennewein, Monika Bubel, Silke Guthörl, Tim Pohlemann, Martin Oberringer

Abstract read
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In one paragraph

Article in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sophie BachmannDepartment of Trauma-, Hand- and Reconstructive Surgery, Saarland University, Kirrberger Straße, Bldng. 57, 66421, Homburg, Germany.
Martina JenneweinDepartment of Trauma-, Hand- and Reconstructive Surgery, Saarland University, Kirrberger Straße, Bldng. 57, 66421, Homburg, Germany.
Monika BubelDepartment of Trauma-, Hand- and Reconstructive Surgery, Saarland University, Kirrberger Straße, Bldng. 57, 66421, Homburg, Germany.
Silke GuthörlDepartment of Trauma-, Hand- and Reconstructive Surgery, Saarland University, Kirrberger Straße, Bldng. 57, 66421, Homburg, Germany.
Tim PohlemannDepartment of Trauma-, Hand- and Reconstructive Surgery, Saarland University, Kirrberger Straße, Bldng. 57, 66421, Homburg, Germany.
Martin OberringerDepartment of Trauma-, Hand- and Reconstructive Surgery, Saarland University, Kirrberger Straße, Bldng. 57, 66421, Homburg, Germany. martin.oberringer@uks.eu.
Saarland University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is growing evidence suggesting that healing of chronic soft tissue wounds profits from the presence of adipose-derived stem cells (ADSC). Among the large spectrum of mechanisms by which ADSC might act, especially the interaction with the microvascular endothelial cell, a main player during angiogenesis, is of special interest. In the present 2D model on the basis of endothelial cell ADSC co-cultures, we focused on the identification of characteristics of both cell types in response to a typical condition in acute and chronic wounds: hypoxia. Parameters like proliferation capacity, migration, myofibroblastoid differentiation of ADSC and the quantification of important paracrine factors related to angiogenesis and inflammation were used to correlate our experimental model with the in vivo situation of soft tissue healing. ADSC were not negatively affected by hypoxia in terms of proliferation, referring to their excellent hypoxia tolerance. Myofibroblastoid differentiation among ADSC was enhanced by hypoxia in mono- but not in co-culture. Furthermore, co-cultures were able to migrate under hypoxia. These effects might be caused to some extent by the distinct milieu created by interacting ADSC and endothelial cells, which was characterized by modulated levels of interleukin-6, interleukin-8, monocyte chemoattractant protein-1 and vascular endothelial growth factor. The identification of these cell characteristics in the present 2D in vitro model provide new insights into the process of human soft tissue healing, and underpin a beneficial role of ADSC by regulating inflammation and angiogenesis.

Indexed as

Adipose TissueAdult Stem CellsCell CommunicationCell DifferentiationCell MovementCell ProliferationCells, CulturedCoculture TechniquesEndothelial CellsHumansMicrovesselsSoft Tissue InjuriesWound HealingAdipose-derived stem cellAngiogenesisCo-cultureHypoxiaInflammationMicrovascular endothelial cellMyofibroblastoid differentiationSoft tissue healing

Identifiers

PMID31583562
OpenAlexW2978939031

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.