Evidence map›Paper›PMID 31583535›Full record

ArticleJournal of nephrology2020

UK renal transplant outcomes in low and high BMI recipients: the need for a national policy.

Ioannis D Kostakis, Theodoros Kassimatis, Valentina Bianchi, Panoraia Paraskeva, Clare Flach, Chris Callaghan, Benedict Lyle Phillips, Nikolaos Karydis, Nicos Kessaris, Francis Calder and 1 more

Abstract read
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In one paragraph

Article in Journal of nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Management of obesity in kidney transplant candidates and recipients: A clinical practice guideline by the DESCARTES Working Group of ERA.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
    Guideline
  3. Pooled it
  4. Article
  5. Article
  6. Review
  7. Article
  8. When There is No Guidance From the Guidelines: Renal Transplantation in Recipients With Class III Obesity.Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Ioannis D KostakisDepartment of Transplantation, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT, UK. i.d.kostakis@gmail.com.ORCID http://orcid.org/0000-0001-6610-4978
Theodoros KassimatisDepartment of Transplantation, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT, UK.
Valentina BianchiDepartment of Transplantation, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT, UK.
Panoraia ParaskevaDepartment of Transplantation, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT, UK.
Clare FlachSchool of Population Health and Environmental Studies, King's College London, London, UK.
Chris CallaghanDepartment of Transplantation, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT, UK.
Benedict Lyle PhillipsDepartment of Transplantation, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT, UK.
Nikolaos KarydisDepartment of Transplantation, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT, UK.
Nicos KessarisDepartment of Transplantation, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT, UK.
Francis CalderDepartment of Transplantation, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT, UK.
Ioannis LoukopoulosDepartment of Transplantation, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT, UK.
Guy's Hospital · GBKing's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe assessed the effect of recipient body mass index (BMI) on the outcomes of renal transplantation and the management of obese patients with end-stage renal disease across the UK.

methodsWe analyzed data of 25539 adult renal transplants (2007-2016) from the UK Transplant Registry. Patients were divided in BMI groups [underweight: < 18.5, normal: 18.5-24.9 (reference group), overweight: 25-29.9, class I obese: 30-34.9, class II/III obese: ≥ 35]. We also conducted a national survey of all UK renal transplant centers on the influence of BMI on decisions regarding management of renal transplant candidates.

resultsBMI ≥ 25 was an independent risk factor for delayed graft function and primary non-function (p ≤ 0.001). Underweight (p = 0.001), class I obese (p = 0.017) and class II/III obese recipients (p < 0.001) had poorer graft survival, however, 5- and 10-year graft survival rates were good. Patient survival was shorter for underweight recipients (p < 0.001) and longer for overweight (p = 0.028) and class I obese recipients (p = 0.013). The national survey revealed significant variability among transplant centers in BMI threshold for listing patients on transplant waiting list and limited support with conservative or surgical procedures for weight control.

conclusionsObesity alone should not be a barrier for renal transplantation. A national strategy is required to give all patients equal chances in transplantation.

Indexed as

Kidney TransplantationAdultAgedBody Mass IndexFemaleGraft SurvivalHumansKidney Failure, ChronicMaleMiddle AgedObesityPostoperative ComplicationsRegistriesRetrospective StudiesSurvival RateThinnessBody mass indexDelayed graft functionGraft survivalObesityPrimary non-functionRecipient survivalRenal transplant

Identifiers

PMID31583535
OpenAlexW2979215966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.